To understand the pollution status of phenolic endocrine disruptors in aquatic products in Shanghai and evaluate the dietary exposure risk of phenolic endocrine disruptors among Shanghai residents.

Based on the monitoring data of phenolic endocrine disruptors in aquatic products sold in Shanghai from 2024 to 2025, combined with the aquatic product consumption data of Shanghai residents in 2024, a simple distribution assessment method was used to evaluate the dietary exposure of phenolic endocrine disruptors in aquatic products.

The overall detection rate of 5 kinds of phenolic endocrine disruptors in 340 aquatic product samples sold in Shanghai was 98.2%. Among them, the detection rate of nonylphenol in aquatic products was 77.4%, the average content was 20.20 μg/kg, and the maximum value was 380.19 μg/kg. The detection rate of bisphenol A in aquatic products was 3.5%, with an average content of 2.29 μg/kg and a maximum value of 190.31 μg/kg. The detection rate of 4-tert-octylphenol in aquatic products was 95.9%, with an average content of 14.14 μg/kg and a maximum value of 345.02 μg/kg. Both 4-n-nonylphenol and 4-n-octylphenol were not detected in aquatic products. According to the analysis of aquatic product types, the average content of nonylphenol in freshwater crabs (39.13 μg/kg) was the highest, followed by marine crabs (34.44 μg/kg). The average content of bisphenol A in freshwater fish (4.69 μg/kg) was the highest, followed by shellfish (3.10 μg/kg). The average content of 4-tert-octylphenol in marine crabs (22.76 μg/kg) was the highest, followed by freshwater shrimps (16.88 μg/kg). The mean daily exposure and P₉₅ exposure of nonylphenol through aquatic products for Shanghai residents aged ≥3 years old were 3.25×10^–2 μg/kg bw and 9.15×10^–2 μg/kg bw, respectively, both of which were much lower than the tolerable daily intake (TDI) of 5 μg/kg bw. The mean daily exposure and P₉₅ exposure of bisphenol A through aquatic products for Shanghai residents were 4.11×10^–3 μg/kg bw and 1.45×10^–2 μg/kg bw, respectively, which were much less than the temporary ADI (4 μg/kg bw). The mean daily exposure and P₉₅ exposure of 4-tert-octylphenol through aquatic products for Shanghai residents were 2.52×10^–2 μg/kg bw and 7.01×10^–2 μg/kg bw, respectively.

The health risks for Shanghai residents from ingesting nonylphenol and bisphenol A solely through aquatic product consumption are relatively low.