Full
Outline
To investigate the chemical composition of red raisins and their mechanism of anti-cerebrocardiac insufficieny by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) combined with network pharmacology.
UPLC-Q-TOF-MS coupled with Insight Explore Ver4.0 screening platform was adopted for rapid qualitative analysis of chemical constituents in red raisin extracts. Network pharmacology was applied to explore the mechanism of red raisins against insufficient cerebral-cardiac blood supply.
A total of 55 chemical constituents were identified from red raisin extracts by UPLC-Q-TOF-MS, mainly polyphenols and flavonoids. A total of 392 functional target of red raisins were screened, among which 264 intersecting targets were shared with insufficient cerebral-cardiac blood supply. The core targets included EGFR, SRC, STAT3, HSP90AA1 and AKT1. The 10 key pathways such as PI3K-Akt, MAPK, lipid and atherosclerosis pathways were mainly regulated to exert therapeutic effects on ameliorating insufficient cerebral-cardiac blood supply.
Red raisins exert therapeutic effects against insufficient cerebral-cardiac blood supply through synergistic regulation of multi-components, multi-targets and multi-pathways. It plays therapeutic roles by improving vascular function, alleviating ischemic injury, inhibiting inflammation and oxidative stress. This study provides scientific basis and experimental support for the development of functional foods, dietary therapy products and processing utilization of red raisins.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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