Full
Outline
To study the effects of the krill oil and oyster soft capsules on bone mineral density, bone metabolism and inflammatory state in ovariectomized rats.
The ovariectomized rat models were established and divided into sham operation group, ovariectomized control group, low, medium and high dose of krill oil and oyster soft capsule groups and calcium carbonate group, which were continuously administered for 3 months.The body weight data were recorded weekly. At the end of the experiment, the changes in body weight, femoral bone calcium content, bone mineral density of the middle and distal femur, and the expression levels of osteoprotegerin(OPG)-receptor activator of nuclear factor kappa-B (RANK)-RANK ligand (RANKL) signaling system related molecules in serum were measured.
The low, medium and high doses of krill oil and oyster soft capsules significantly increased femoral bone calcium content and bone mineral density of distal femur in ovariectomized rats;middle and high doses of krill oil and oyster soft capsules could significantly increase bone mineral density of middle femur, which was not lower than that of calcium carbonate treatment group. The results of bone metabolism markers showed that the expression levels of alkaline phosphatase, osteocalcin and procollagen type I amino acid propeptide significantly increased in the high dose group of kril oil and oyster soft capsules, while the expression levels of bone alkaline phosphatase and C-telopeptide of type I collagen were significantly inhibited in the low, medium and high dose groups. The results of OPG-RANKL-RANK signaling system related molecular detection showed that the low-dose kril oil and oyster soft capsules significantly inhibited the levels of osteoprotegerin, and the medium and high dose significantly inhibited the levels of osteoprotegerin, interleukin-6 and interleukin-8 in serum of ovariectomized rats, and significantly increased the level of transforming growth factor-β1.
The krill oil and oyster soft capsules can improve bone mineral density, bone metabolism and ameliorate inflammatory state in ovariectomized rats through multiple mechanisms such as providing calcium source, maintaining the balance between bone formation and bone resorption, anti-inflammation, regulating OPG-RANKL-RANK signaling system, and reducing high bone turnover rate.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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