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Optimization of extraction process and evaluation of immune regulating activity of compound Polygonati rhizoma ointment
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Xian LIAO1, Zhao-Qi YU1, Chun-Ming WANG2, Jing-Wen YU1, Meng LI3, Chun-Miao YU1, *
Journal of Food Safety & Quality | 2026, 17(10) : 46 - 57
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Journal of Food Safety & Quality | 2026, 17(10): 46-57
• Special Topic: Development and Detection of Health Foods •
Optimization of extraction process and evaluation of immune regulating activity of compound Polygonati rhizoma ointment
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Xian LIAO1, Zhao-Qi YU1, Chun-Ming WANG2, Jing-Wen YU1, Meng LI3, Chun-Miao YU1, *
Affiliations
  • 1.College of Pharmacy, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China
  • 2.Harbin Yuyantang Traditional Chinese Medicine Clinic Co., Ltd., Harbin 150040, China
  • 3.Heilongjiang Provincial Green Food Science Research Institute, Harbin 150040, China
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251224002
Outline
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Objective

To optimize the extraction process of the functional components of compound Polygonati rhizoma ointment and evaluate its immune regulating activity.

Methods

Using crude polysaccharides, total saponins, cordycepin content and dry extract rate as evaluation indicators, the extraction process parameters were optimized through analytic hierarchy process (AHP)-criteria importance through intercriteria correlation (CRITIC)mixed weighting method and Box-Behnken design response surface methodology. Carbon clearance test, delayed type hypersensitivity test and serum hemolysin test were used to evaluate its immune regulating activity.

Results

The optimal extraction process for the functional components of compound Polygonati rhizoma ointment was 117 min of extraction time, 3 times of extraction, extraction temperature of 94 ℃ and a solid-liquid ratio of 1:14 (g:mL).Compound Polygonati rhizoma ointment could enhance the delayed type hypersensitivity ability of mice, improve the phagocytic ability of monocytes macrophages and increase the content of serum hemolysin.

Conclusion

The process is reasonable and feasible, and the compound Polygonati rhizoma ointment extracted under the optimal process has good immune regulatory activity, providing a reference for the further development and application of compound Polygonati rhizoma ointment.

compound Polygonati rhizoma ointment  /  extraction process optimization  /  mice  /  immune regulating activity
廖贤, 于肇麒, 王春明, 于静文, 李猛, 于纯淼. 复方黄精膏提取工艺优化及其免疫调节活性评价. 食品安全质量检测学报, 2026 , 17 (10) : 46 -57 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251224002
Xian LIAO, Zhao-Qi YU, Chun-Ming WANG, Jing-Wen YU, Meng LI, Chun-Miao YU. Optimization of extraction process and evaluation of immune regulating activity of compound Polygonati rhizoma ointment[J]. Journal of Food Safety & Quality, 2026 , 17 (10) : 46 -57 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251224002
Appendix
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Year 2026 volume 17 Issue 10
6
1
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251224002
  • Receive Date：2025-12-24
  • Online Date：2026-11-05
Article Data
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History
  • Received：2025-12-24
Funding
Affiliations
    1.College of Pharmacy, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China
    2.Harbin Yuyantang Traditional Chinese Medicine Clinic Co., Ltd., Harbin 150040, China
    3.Heilongjiang Provincial Green Food Science Research Institute, Harbin 150040, China
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https://castjournals.cast.org.cn/joweb/spaq/EN/10.19812/j.cnki.jfsq11-5956/ts.20251224002
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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