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Determination of 6 kinds of quinolone residues in eggs by solid-phase extraction combined with liquid chromatography-tandem triple quadrupole mass spectrometry
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Ben-Yang LV1, Sheng-Xiu DING1, Zhong-Chun LI2, Jing XU1, Wei LI1, Wen-Jun DING1, Ming-Jia BAO3, *, Feng-Hai LIU1, *
Journal of Food Safety & Quality | 2026, 17(4) : 121 - 128
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Journal of Food Safety & Quality | 2026, 17(4): 121-128
• Special Topic: Detection, Analysis and Control of Pesticide and Veterinary Drug Residue •
Determination of 6 kinds of quinolone residues in eggs by solid-phase extraction combined with liquid chromatography-tandem triple quadrupole mass spectrometry
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Ben-Yang LV1, Sheng-Xiu DING1, Zhong-Chun LI2, Jing XU1, Wei LI1, Wen-Jun DING1, Ming-Jia BAO3, *, Feng-Hai LIU1, *
Affiliations
  • 1.School of Public Health, Mudanjiang Medical University, Mudanjiang 157011, China
  • 2.Mudanjiang Center for Disease Control and Prevention, Mudanjiang 157021, China
  • 3.Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150030, China
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251023008
Outline
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Objective

To establish a method for the determination of 6 kinds of quinolone residues (ofloxacin, norfloxacin, lomefloxacin, pefloxacin, enrofloxacin and ciprofloxacin) in eggs by solid-phase extraction combined with liquid chromatography-tandem triple quadrupole mass spectrometry.

Methods

Egg samples were extracted with 0.1 mol/L ethylenediaminetetraacetic acid-Mcllvaine (EDTA-Mcllvaine) buffer, purified by HLB solid-phase extraction cartridges and separated on an Acquity BEH C18 column (100 mm×2.1 mm, 1.7 μm) using a gradient elution with methanol-acetonitrile (4:6, V:V) and 0.2% formic acid aqueous solution as the mobile phase. The analytes were detected in positive electrospray ionization (ESI+) mode with multiple reaction monitoring (MRM), quantified using a matrix-matched calibration curve.

Results

The 6 kinds of quinolones exhibited good linearity in the range of 1.0–100.0 μg/kg with correlation coefficients (r2) more than 0.999. The limits of detection and limits of quantitation were 0.13–0.25 μg/kg and 0.43–0.83 μg/kg, respectively. The average recoveries ranged from 94.6% to 108.0%, with relative standard deviations of 2.48%–6.34% (n=3).

Conclusion

The developed method is simple, sensitive and robust, suitable for the rapid detection of quinolone residues in eggs, providing technical support for food safety monitoring.

quinolones  /  liquid chromatography-tandem triple quadrupole mass spectrometry  /  solid-phase extraction  /  egg
吕奔阳, 丁圣修, 李忠春, 徐婧, 李伟, 丁文均, 包名家, 刘凤海. 固相萃取-液相色谱-串联三重四极杆质谱法检测鸡蛋中6种喹诺酮类药物含量. 食品安全质量检测学报, 2026 , 17 (4) : 121 -128 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251023008
Ben-Yang LV, Sheng-Xiu DING, Zhong-Chun LI, Jing XU, Wei LI, Wen-Jun DING, Ming-Jia BAO, Feng-Hai LIU. Determination of 6 kinds of quinolone residues in eggs by solid-phase extraction combined with liquid chromatography-tandem triple quadrupole mass spectrometry[J]. Journal of Food Safety & Quality, 2026 , 17 (4) : 121 -128 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251023008
Appendix
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Year 2026 volume 17 Issue 4
16
7
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251023008
  • Receive Date：2025-10-23
  • Online Date：2026-11-05
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History
  • Received：2025-10-23
Funding
Affiliations
    1.School of Public Health, Mudanjiang Medical University, Mudanjiang 157011, China
    2.Mudanjiang Center for Disease Control and Prevention, Mudanjiang 157021, China
    3.Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150030, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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