Full
Outline
To explore the potential of β-nicotinamide mononucleotide (β-NMN) in regulating blood glucose balance through antioxidant mechanisms.
A high glucose model rat was established by injecting 105 mg/kg·BW alloxan and feeding it with high-fat diet. SD rats were given different doses of β-NMN for 30 consecutive days. Meanwhile, a normal animal control group was set up. At the end of the experiment, the blood glucose, blood lipids and antioxidant-related factors in the rat serum were measured.
β-NMN had a certain regulatory effect on the blood glucose of alloxan model high-glucose rats. The 40 mg/kg dose group of β-NMN could significantly reduce the blood glucose of the model rats (P<0.05), and compared with the model group, the area under the curve (AUC) of the 0–2 h curve of this dose group decreased by 6.77% (P<0.05). The contents of serum cholesterol (CHO) and triglyceride (TG) in this dose group were significantly reduced (P<0.05). The insulin resistance index of each dose group was significantly reduced (P<0.01), and there was no adverse effect on the blood glucose of normal rats. In the determination results of antioxidant-related factors, alloxan caused oxidative stress in the rats, and the activity of superoxide dismutase (SOD) in the 20 mg/kg β-NMN group increased by 5.69% (P<0.01), the content of glutathione (GSH) in the 4 mg/kg and 40 mg/kg groups increased by 27.36% and 23.79% (P<0.01), the protein carbonyl content in the 40 mg/kg group decreased by 28.20% (P<0.05), and the content of malondialdehyde(MDA) and receptor for advanced glycation end products (RAGE/AGER) in each dose group were significantly lower than those of the model group (P<0.05, P<0.01).
β-NMN can enhance the endogenous antioxidant capacity through the nicotinamide adenine dinucleotide-SIRT1-FoxO3a/PGC-1α axis, inhibit secondary oxidative damage mediated by RAGE, and thereby maintain blood glucose balance. This provides a theoretical basis for the future research and application of functional products.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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