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Detection of illegally added quinolone drugs in health foods by high performance liquid chromatography-tandem mass spectrometry
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Wei-E ZHOU1, 2, Qi-Zhi CHANG1, 2, 3, Mei-Xia XU1, 2, Chang WANG1, 2, Feng FENG1, 2, *
Journal of Food Safety & Quality | 2026, 17(9) : 147 - 156
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Journal of Food Safety & Quality | 2026, 17(9): 147-156
• Special Topic: Functional Foods and Functional Components •
Detection of illegally added quinolone drugs in health foods by high performance liquid chromatography-tandem mass spectrometry
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Wei-E ZHOU1, 2, Qi-Zhi CHANG1, 2, 3, Mei-Xia XU1, 2, Chang WANG1, 2, Feng FENG1, 2, *
Affiliations
  • 1.Institute of Food Safety, Chinese Academy of Quality and Inspection & Testing, Beijing 100176, China
  • 2.Key Laboratory of Food Quality and Safety, State Administration for Market Regulation, Beijing 100176, China
  • 3.School of Pharmacy, China Medical University, Shenyang 110122, China
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251222001
Outline
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Objective

To establish a method for the detection of 4 kinds of quinolone drugs illegally added to anti-inflammatory health foods by high performance liquid chromatography-tandem mass spectrometry.

Methods

The sample was dissolved in acetonitrile, extracted by sonication, purified using a modified QuEChERS method with low-temperature centrifugation, separated using a C18 chromatographic column, and then analyzed using multiple reaction monitoring in positive ion mode with an electrospray ionization source.

Results

This method showed good linearity for 4 kinds of quinolone drugs, with a correlation coefficient (r) greater than 0.997. The limits of detection were 0.01–0.02 mg/kg, the limits of quantitation were 0.02–0.05 mg/kg, the recoveries rates were 70.16%–109.26% and the precisions were 1.27%–4.56%.

Conclusion

This method is accurate, simple and easy to implement, enabling accurate detection of quinolone drugs illegally added to anti-inflammatory health foods, and providing technical support for risk monitoring of illegally added quinolone drugs in health foods.

anti-inflammatory  /  health foods  /  illegal additives  /  quinolone drugs  /  high performance liquid chromatography-tandem mass spectrometry
周伟娥, 常启智, 徐美霞, 王畅, 冯峰. 高效液相色谱-串联质谱法检测保健食品中非法添加的喹诺酮类药物. 食品安全质量检测学报, 2026 , 17 (9) : 147 -156 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251222001
Wei-E ZHOU, Qi-Zhi CHANG, Mei-Xia XU, Chang WANG, Feng FENG. Detection of illegally added quinolone drugs in health foods by high performance liquid chromatography-tandem mass spectrometry[J]. Journal of Food Safety & Quality, 2026 , 17 (9) : 147 -156 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251222001
Appendix
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Year 2026 volume 17 Issue 9
7
1
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251222001
  • Receive Date：2025-12-22
  • Online Date：2026-11-05
Article Data
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History
  • Received：2025-12-22
Funding
Affiliations
    1.Institute of Food Safety, Chinese Academy of Quality and Inspection & Testing, Beijing 100176, China
    2.Key Laboratory of Food Quality and Safety, State Administration for Market Regulation, Beijing 100176, China
    3.School of Pharmacy, China Medical University, Shenyang 110122, China
References
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https://castjournals.cast.org.cn/joweb/spaq/EN/10.19812/j.cnki.jfsq11-5956/ts.20251222001
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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