Home Journals Articles Updates About
CN
image
收藏切换
Determination of residual levels of tildipirosin in raw milk by high performance liquid chromatography tandem mass spectrometry
收藏切换
Mo LI1, 2, Zheng LV1, 2, Ting ZHOU2, Chun-Ming WANG1, 2, Qian WANG2, Jing-Jian JIA1, 2, Ke-Jing LI1, 2, *, Tao PENG1, 2, *
Journal of Food Safety & Quality | 2026, 17(6) : 280 - 286
Less
收藏切换
Journal of Food Safety & Quality | 2026, 17(6): 280-286
• Food Analysis and Detection •
Determination of residual levels of tildipirosin in raw milk by high performance liquid chromatography tandem mass spectrometry
Full
Mo LI1, 2, Zheng LV1, 2, Ting ZHOU2, Chun-Ming WANG1, 2, Qian WANG2, Jing-Jian JIA1, 2, Ke-Jing LI1, 2, *, Tao PENG1, 2, *
Affiliations
  • 1.CAIQ (Beijing) Testing and Certification Co., Ltd., Beijing 100176, China
  • 2.China Academy of Quality Inspection and Testing, Beijing 100176, China
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251126002
Outline
收藏切换
Objective

To establish an analytical method for detection of residual tildipirosin in raw milk by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).

Methods

The sample was extracted with acid acetonitrile, purified by enhanced matrix removal (EMR) purification column, and then separated by BEH C18. The target compound was analyzed by a positive electrospray ion multiple reaction monitoring mode and quantitative analysis using matrix matching isotope internal standard method for quantification.

Results

The calibration curves were linear in the range of 2.5–100.0 ng/mL with correlation coefficients more than 0.99. The limit of detection was 2.5 μg/kg, limit of quantitation was 5.0 μg/kg. The average recoveries at different addition concentrations ranged from 78.2% to 97.6%, with the relative stand deviations of the determination results ranged from 6.02% to 7.69%.

Conclusion

This method is accuracy, sensitive stability, simple and easy to operate, which can be used to determinate of residual amounts of tildipirosin in raw milk.

tildipirosin  /  high performance liquid chromatography-tandem mass spectrometry  /  purification column  /  raw milk
李默, 吕铮, 周婷, 汪春明, 王倩, 贾景健, 李克静, 彭涛. 高效液相色谱-串联质谱法测定生牛乳中泰地罗新残留量. 食品安全质量检测学报, 2026 , 17 (6) : 280 -286 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251126002
Mo LI, Zheng LV, Ting ZHOU, Chun-Ming WANG, Qian WANG, Jing-Jian JIA, Ke-Jing LI, Tao PENG. Determination of residual levels of tildipirosin in raw milk by high performance liquid chromatography tandem mass spectrometry[J]. Journal of Food Safety & Quality, 2026 , 17 (6) : 280 -286 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251126002
Appendix
Less
Year 2026 volume 17 Issue 6
10
1
Cite this Article
BibTeX
Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251126002
  • Receive Date：2025-11-26
  • Online Date：2026-11-05
Article Data
Affiliations
History
  • Received：2025-11-26
Funding
Affiliations
    1.CAIQ (Beijing) Testing and Certification Co., Ltd., Beijing 100176, China
    2.China Academy of Quality Inspection and Testing, Beijing 100176, China
References
Share
https://castjournals.cast.org.cn/joweb/spaq/EN/10.19812/j.cnki.jfsq11-5956/ts.20251126002
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House