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Outline
To assess the dietary exposure to aflatoxin B1 (AFB1) and health risks among residents in high and normal consumption areas of home-made Arachis hypogaea oil in Guangzhou City.
Dietary surveys and Monte Carlo simulation were conducted to estimate the daily exposure to AFB1 from edible oils, rice,flour, corn and nuts (samples were collected from 2019 to 2024). The margin of exposure (MOE) method was used for risk characterization. Additionally, enzyme-linked immunosorbent assay was employed to detect the levels of AFB1 albumin adducts (AFB1-A1b) in the serum of residents collected from 2022 to 2024 to verify the results.
The AFB1 exposure level in residents of the consumption areas was significantly higher than that in residents of the normal consumption areas. Based on a conservative estimate using a POD value of 78 ng/kg bw/day,the average MOE values were 27.21 and 34.16, respectively (P<0.001). The results of serum biomarker detection were consistent, with the AFB1-A1b level in the high consumption area [(4.59±3.86) ng/mL] significantly higher than that in the normal consumption area [(3.97±4.74) ng/mL] (P<0.001).
This study shows that the AFB1 exposure risk of residents in the high consumption area of home-made Arachis hypogaea oil in Guangzhou City is relatively higher than that in the normal consumption area, and home-made Arachis hypogaea oil is the main contributing factor. The study suggests that supervision over the production and circulation of home-made Arachis hypogaea oil shall be strengthened, and refined oil shall be promoted as a substitute in high-risk areas to reduce residents’ exposure and related health risks. This study focuses on different consumption areas of traditionally pressed Arachis hypogaea oil within Guangzhou, quantifies the impact of consumption levels on AFB1 exposure risk, and provides direct evidence for the implementation of risk control measures.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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