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Determination of multiple fluoroquinolones and benzodiazepines in aquatic products by ultra performance liquid chromatography-tandem mass spectrometry with pass-through solid phase extraction
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Ding-Nan WANG1, Xin-Ya WU2, Shi-Yan LI1, Qin ZHOU1, Qing-Qing KE1, Yi-Ming ZHANG2, Yang WANG1, *
Journal of Food Safety & Quality | 2025, 16(13) : 26 - 36
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Journal of Food Safety & Quality | 2025, 16(13): 26-36
• Highlight: Processing and Quality Safety of Aquatic Products •
Determination of multiple fluoroquinolones and benzodiazepines in aquatic products by ultra performance liquid chromatography-tandem mass spectrometry with pass-through solid phase extraction
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Ding-Nan WANG1, Xin-Ya WU2, Shi-Yan LI1, Qin ZHOU1, Qing-Qing KE1, Yi-Ming ZHANG2, Yang WANG1, *
Affiliations
  • 1 Zhejiang Fisheries Technical Extension Station, Hangzhou 310023, China
  • 2 College of Food and Health, Zhejiang A&F University, Hangzhou 311300, China
Published: 2025-07-15 doi: 10.19812/j.cnki.jfsq11-5956/ts.20250409008
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Objective To establish an analytical method for the simultaneous determination of 6 kinds of fluoroquinolones and 4 kinds of benzodiazepines residues in aquatic products by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Methods Aquatic product samples were extracted with 1% formic acid in acetonitrile. The extracts were concentrated with a rotary evaporator and then reconstituted in 90% acetonitrile aqueous solution (containing 1% formic acid), and purified through a pass-through solid phase extraction cartridge (ProElut PLS-A). The purified extracts were directly analyzed by UPLC-MS/MS. Quantification was performed using the isotope internal standard method. Results The 10 kinds of target compounds exhibited good linearity within the concentration range of 0.5 to 50.0 ng/mL, with correlation coefficients (r) all greater than 0.998. The limits of quantitation for these compounds in 5 kinds of different aquatic product matrices ranged from 0.5 to 1.0 μg/kg. The recovery rates at low, medium and high spiking levels ranged from 81.5% to 109.7%, with relative standard deviations ranging from 0.24% to 13.22%. Conclusion Methodological validation confirmed that the developed method is highly sensitive, accurate in quantification, stable, and straightforward in operation. It is suitable for high-throughput detection of 6 kinds of fluoroquinolones and 4 kinds of benzodiazepines residues in aquatic products.

fluoroquinolones  /  benzodiazepines  /  aquatic products  /  pass-through solid phase extraction
Ding-Nan WANG, Xin-Ya WU, Shi-Yan LI, Qin ZHOU, Qing-Qing KE, Yi-Ming ZHANG, Yang WANG. Determination of multiple fluoroquinolones and benzodiazepines in aquatic products by ultra performance liquid chromatography-tandem mass spectrometry with pass-through solid phase extraction[J]. Journal of Food Safety & Quality, 2025 , 16 (13) : 26 -36 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20250409008
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Year 2025 volume 16 Issue 13
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20250409008
  • Receive Date：2025-04-09
  • Online Date：2026-01-12
  • Published：2025-07-15
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  • Received：2025-04-09
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    1 Zhejiang Fisheries Technical Extension Station, Hangzhou 310023, China
    2 College of Food and Health, Zhejiang A&F University, Hangzhou 311300, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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