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Determination of 2 kinds of new carbadenafil analogue in tablet candies and solid beverages by high performance liquid chromatography
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Wan-Qin WU1, 2, 3, Feng JIANG1, 2, 3, Song-Song ZHU1, 2, 3, Jin-Tao XIA1, 2, 3, Xiao-Long FAN1, 2, 3, *, Ya-Zhen ZHANG1, 2, 3, Zhi HAN1, 2, 3, Li ZHANG1, 2, 3, Meng FENG4
Journal of Food Safety & Quality | 2025, 16(3) : 235 - 240
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Journal of Food Safety & Quality | 2025, 16(3): 235-240
• Food Analysis and Detection •
Determination of 2 kinds of new carbadenafil analogue in tablet candies and solid beverages by high performance liquid chromatography
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Wan-Qin WU1, 2, 3, Feng JIANG1, 2, 3, Song-Song ZHU1, 2, 3, Jin-Tao XIA1, 2, 3, Xiao-Long FAN1, 2, 3, *, Ya-Zhen ZHANG1, 2, 3, Zhi HAN1, 2, 3, Li ZHANG1, 2, 3, Meng FENG4
Affiliations
  • 1. Hubei Provincial Institute for Food Supervision and Test, Wuhan 430075, China
  • 2. Key Laboratory of Detection Technology of Focus Chemical Hazards in Animal-derived Food, State Administration for Market Regulation, Wuhan 430075, China
  • 3. Hubei Shizhen Laboratory, Wuhan 430065, China
  • 4. Waters Corporation, Shanghai 201206, China
Published: 2025-02-15 doi: 10.19812/j.cnki.jfsq11-5956/ts.20240828002
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Objective To establish a method for determination of 2 kinds of new carbadenafil analogue in tablet candies and solid beverages by high performance liquid chromatography. Methods The sample was extracted by methanol ultrasound, the extract was centrifuged, filtered through a microporous membrane, and analyzed by the high performance liquid chromatography. The separation was performed on a Waters Xbridge C18 column (250 mm×4.6 mm, 5 μm) with gradient elution by using 20 mmol/L ammonium acetate aqueous solution and methanol as the mobile phase, and quantified by external standard method. Results The 2 kinds of new carbadenafil analogue demonstrated good linearity in the range of 0.5-100.0 μg/mL, with the correlation coefficient values (r2) being higher than 0.999. The limits of quantification were found to be 5 mg/kg. The recoveries at 3 spiked levels of 1, 2 and 10 times the limits of quantification in blank matrix were in the range of 87.32%-93.92%, with the relative standard deviations between 1.19%-4.08%. A total of 8 batches of positive samples were detected using this method, with a content range of 218-2170 mg/kg. Conclusion The method is convenient, accurate and efficient. It can meet the identification requirement of illegally added 2 kinds of new carbadenafil analogue in tablet candies and solid beverages, and provide effective technical support to combat the illegal addition of new carbadenafil analogue in food.

high performance liquid chromatography  /  carbadenafil analogue  /  tablet candies  /  solid beverages  /  illegal additions
Wan-Qin WU, Feng JIANG, Song-Song ZHU, Jin-Tao XIA, Xiao-Long FAN, Ya-Zhen ZHANG, Zhi HAN, Li ZHANG, Meng FENG. Determination of 2 kinds of new carbadenafil analogue in tablet candies and solid beverages by high performance liquid chromatography[J]. Journal of Food Safety & Quality, 2025 , 16 (3) : 235 -240 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20240828002
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Year 2025 volume 16 Issue 3
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20240828002
  • Receive Date：2024-08-28
  • Online Date：2025-07-21
  • Published：2025-02-15
Article Data
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History
  • Received：2024-08-28
Funding
Affiliations
    1. Hubei Provincial Institute for Food Supervision and Test, Wuhan 430075, China
    2. Key Laboratory of Detection Technology of Focus Chemical Hazards in Animal-derived Food, State Administration for Market Regulation, Wuhan 430075, China
    3. Hubei Shizhen Laboratory, Wuhan 430065, China
    4. Waters Corporation, Shanghai 201206, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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