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Effects of sub-chronic exposure to paralytic shellfish toxins on liver lipidomics in mice
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Xiao-Xiao WANG1, Cai-Hong CHEN1, Guan-Chao ZHENG2, Shan-Qin HUO2, Zhi-Jun TAN2, Hai-Yan WU2, *
Journal of Food Safety & Quality | 2025, 16(3) : 8 - 16
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Journal of Food Safety & Quality | 2025, 16(3): 8-16
• Special Topic: Detection and Prevention and Control of Biotoxins in Food •
Effects of sub-chronic exposure to paralytic shellfish toxins on liver lipidomics in mice
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Xiao-Xiao WANG1, Cai-Hong CHEN1, Guan-Chao ZHENG2, Shan-Qin HUO2, Zhi-Jun TAN2, Hai-Yan WU2, *
Affiliations
  • 1. College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China
  • 2. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China
Published: 2025-02-15 doi: 10.19812/j.cnki.jfsq11-5956/ts.20240919003
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Objective To evaluate the effects of sub-chronic doses of paralytic shellfish toxins (PSTs) on the livers of mice. Methods In the present study, the effects of different dose concentrations PSTs on hepatic lipid metabolomics were assessed by oral gavage using the lipidomics technique. Results Exposure to the high-and medium-dose group (greater than 100 µg STXeq/kg BW) resulted in abnormal lipid metabolism, with glycerophospholipids (GP) as the major differential lipid metabolites, phosphatidylethanolamine (18:3/22:6) [PE (18:3/22:6)], PE (16:0/18:0), and 16(17)-epoxydocosapentaenoic acid were lower, whereas the relative content of lysophosphatidylethanolamine (P-16:0/0:0) was elevated in relative levels of these lipids, which might serve as biomarkers of liver injury due to PSTs exposure. In contrast, the low dose group (45 µg STXeq/kg BW) did not significantly affect mouse liver lipids. Metabolic pathway enrichment analysis of differential lipids showed that α-linolenic acid metabolism, glyceride metabolism, arachidonic acid metabolism, and steroid hormone biosynthesis were collectively involved in lipid metabolism in the 3 kinds of PSTs experimental groups. Conclusion The effects of PSTs on hepatic lipid metabolism in mice are characterized by a dose-dependent pattern, and lipid dysfunction may affect the neurotoxic effects of PSTs. This study provides a theoretical reference for exploring the mechanism of hepatic injury by PSTs in mice.

paralytic shellfish toxins  /  lipidomics  /  differential lipids  /  metabolic pathways
Xiao-Xiao WANG, Cai-Hong CHEN, Guan-Chao ZHENG, Shan-Qin HUO, Zhi-Jun TAN, Hai-Yan WU. Effects of sub-chronic exposure to paralytic shellfish toxins on liver lipidomics in mice[J]. Journal of Food Safety & Quality, 2025 , 16 (3) : 8 -16 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20240919003
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Year 2025 volume 16 Issue 3
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20240919003
  • Receive Date：2024-09-19
  • Online Date：2025-07-21
  • Published：2025-02-15
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  • Received：2024-09-19
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Affiliations
    1. College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China
    2. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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