Objective To understand the prevalence, serotype distribution and drug resistance of Salmonella from foodborne diseases in Fengtai District, Beijing from 2016 to 2023. Methods Salmonella was isolated and identified from the stool samples of foodborne diseases. Serotypes of Salmonella were identified by slide agglutination test. The antimicrobial resistance of Salmonella was determined by micro broth dilution method and minimum inhibitory concentration method. Results The detection rate of Salmonella was 4.33%, which increased from 2.11% to 9.28% from 2016 to 2023. Salmonella infection peaked in autumn. The detection rate of Salmonella was higher in people aged 0-9 old years and 40-49 old years, and people of fever, nausea and diarrhea more than 6. The consumption of meat and meat products was the risk factor of Salmonella infection. The top 5 serotypes were Salmonella enteritidis, Salmonella typhimurium, Salmonella thompson, Monophasic salmonella enterica serovar typhimurium and Salmonella senftenberg. There was an upward trend in the detection rate of Salmonella thompson, and Monophasic salmonella enterica serovar typhimurium. The resistance rate of Salmonella to nalidixic acid (NAL), ampicillin (AMP) and ampicillin-sulbactam (AMS) was higher, the intermediate rate of Salmonella to ciprofloxacin (CIP) was higher, and the sensitivity of Salmonella to gentamicin (GEN), imipenem (IMI) and azithromycin (AZI) was higher. The drug resistance of Salmonella enteritidis was the most serious, the drug resistance rate of tetracycline (TET) and ceftazidime (CAZ) was increasing, and the intermediate rate of CIP was decreasing. The multi-drug resistance rate of Salmonella was 44.00%, which included 31 drug resistance profiles. Conclusion The detection rates of Salmonella are different in different age, different symptoms and food exposure history of people, and different season. Salmonella enteritidis is the main serotype. The serum distribution of Salmonella is dispersive. The resistances of Salmonella to quinolones antibiotics and β-lactam antibiotics are serious, and the situation of multi-drug resistance is serious. We should enhance food safety education on Salmonella, strengthen surveillance on meat food safety, strengthen surveillance on new salmonella species such as Monophasic salmonella enterica serovar typhimurium, strengthen the use of antibiotics, and optimize measures for disease prevention and control of Salmonella.