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Regulation of gut microbiota by mannans and their intervention in glucose and lipid metabolic diseases
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He-Yang XU1, 2, Peng-Kui XIA1, 2, Bin LI1, 2, Jing LI1, 2, *
Journal of Food Safety & Quality | 2025, 16(7) : 136 - 147
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Journal of Food Safety & Quality | 2025, 16(7): 136-147
• Special Topic: Functional Foods and Functional Components •
Regulation of gut microbiota by mannans and their intervention in glucose and lipid metabolic diseases
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He-Yang XU1, 2, Peng-Kui XIA1, 2, Bin LI1, 2, Jing LI1, 2, *
Affiliations
  • 1. College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
  • 2. Key Laboratory of Environment Correlative Dietology, Ministry of Education, Wuhan 430070, China
Published: 2025-04-15 doi: 10.19812/j.cnki.jfsq11-5956/ts.20241224002
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In recent years, the incidence of glucose and lipid metabolism-related diseases has increased significantly, often accompanied by dysbiosis of the gut microbiota. Mannans, as a class of functional polysaccharides with diverse sources, play an important role in regulating the gut microbiota and impacting host health, garnering widespread attention. This review delved into the structural characterization of glucomannans, galactomannans, and mannan oligosaccharides from various sources, with particular emphasis on the impact of mannans on the gut microbiota and their potential applications in precision nutrition. Studies indicated that mannans could selectively promote the growth of probiotics such as Bifidobacterium and Lactobacillus, while inhibiting the proliferation of pathogens like Escherichia coli, affecting the production of short-chain fatty acids and the metabolism of branched-chain amino acids, thereby optimizing the structure and function of the gut microbiota. The review also summarized the intestinal fermentability of mannans and their health benefits in metabolic diseases such as diabetes, hyperlipidemia, and obesity, offering new intervention strategies for the prevention and treatment of various chronic diseases.

mannans  /  gut microbiota  /  short-chain fatty acids  /  glucose and lipid metabolism
He-Yang XU, Peng-Kui XIA, Bin LI, Jing LI. Regulation of gut microbiota by mannans and their intervention in glucose and lipid metabolic diseases[J]. Journal of Food Safety & Quality, 2025 , 16 (7) : 136 -147 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20241224002
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Year 2025 volume 16 Issue 7
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20241224002
  • Receive Date：2024-12-24
  • Online Date：2025-07-19
  • Published：2025-04-15
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  • Received：2024-12-24
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    1. College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
    2. Key Laboratory of Environment Correlative Dietology, Ministry of Education, Wuhan 430070, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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