PDF
Full
Outline
Objective To explore the effects of dried Dendrobium officinale and fresh Dendrobium officinale on the gut microbiota of normal mice and to provide a reference for its rational development and application. Methods The normal mice were administrated with dried Dendrobium officinale and fresh Dendrobium officinale for 7 days, respectively. The growth of mice was observed, and the mucosa-associated microbiota in the small intestine and colon was detected using the full-length 16S rRNA gene sequencing. Results The results showed that both dried Dendrobium officinale and fresh Dendrobium officinale could control the weight gain of mice, but the weight-control effect of fresh Dendrobium officinale was more significant than that of dried Dendrobium officinale. Both dried Dendrobium officinale and fresh Dendrobium officinale decreased α diversity of mucosa-associated microbiota in the colon. However, fresh Dendrobium officinale increased α diversity of mucosa-associated microbiota in the small intestine, while the effect of dried Dendrobium officinale was the opposite. Moreover, fresh Dendrobium officinale significantly promoted the proliferation of short-chain fatty acid-producing bacteria (Lactobacillus, Faecalibacterium prausnitzii, Butyricicoccus pullicaecorum and Roseburia inulinivorans) in the small intestine and up-regulated metabolic pathways such as lipid metabolism, metabolism of terpenoids and polyketides, carbohydrate metabolism, and xenobiotics biodegradation and metabolism. In colonic mucosa-associated microbiota, dried Dendrobium officinale showed a stronger inhibitory effect on Escherichia coli and Ruminococcus gnavus than fresh Dendrobium officinale. Conclusion The results show that fresh Dendrobium officinale can control body weight and maintain health by promoting the proliferation of beneficial bacteria and up-regulating lipid and carbohydrate metabolism, while dried Dendrobium officinale can inhibit the growth of harmful bacteria, and may help reduce the potential risk of disease.
PDF
252
113
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
