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Effects of B-type proanthocyanidins trimer from Litchi chinensis Sonn pulp on regulating lipid metabolism in hepatocytes
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Guang-Yi LUO1, Ye-Jie WEN2, Rui-Fen ZHANG2, Mei DENG2, Ming-Wei ZHANG2, Xu-Chao JIA2, Kun HU1, *
Journal of Food Safety & Quality | 2025, 16(5) : 69 - 75
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Journal of Food Safety & Quality | 2025, 16(5): 69-75
• Special Topic: Functional Foods and Functional Components •
Effects of B-type proanthocyanidins trimer from Litchi chinensis Sonn pulp on regulating lipid metabolism in hepatocytes
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Guang-Yi LUO1, Ye-Jie WEN2, Rui-Fen ZHANG2, Mei DENG2, Ming-Wei ZHANG2, Xu-Chao JIA2, Kun HU1, *
Affiliations
  • 1. College of Food Science, Guangdong Pharmaceutical University, Zhongshan 528400, China
  • 2. Sericultural & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510000, China
Published: 2025-03-15 doi: 10.19812/j.cnki.jfsq11-5956/ts.20241120002
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Objective To explore the dose effects and molecular mechanism of B-type proanthocyanidins trimer, the main active component of Litchi chinensis Sonn pulp phenolics, on hepatocyte triglyceride (TG) deposition. Methods HepG2 cell steatosis model induced by oleic acid (OA) was treated with different mass concentrations (0.5-10.0 μg/mL) of B-type proanthocyanidins trimer. The content of TG and the expressions of genes related to lipid absorption, transport and oxidation, together with apoptosis of hepatocytes, were detected in oleic acid loaded hepatocytes. Results B-type proanthocyanidins trimer (0.5-10.0 μg/mL) all significantly inhibited TG accumulation in oleic acid-loaded hepatocytes, while no dose dependence was observed. Low-dose (1.0 μg/mL) B-type proanthocyanidins trimer inhibited hepatocyte apoptosis by increasing the relative expression ratio of Bcl-2 to Bax, thereby reducing TG accumulation in hepatocytes. In addition to the above-mentioned pathway, medium/high-dose (5.0 μg/mL, 10.0 μg/mL) B-type proanthocyanidins trimer also inhibited lipid absorption in hepatocytes by down-regulating CD36 and FATP2 expression, and promoted hepatocytes lipolysis by up-regulating ACSL1 and CPT1α expression, hence reducing TG accumulation in hepatocytes. Conclusion B-type proanthocyanidins trimer of Litchi chinensis Sonn pulp can inhibit lipid absorption, promote β-oxidation of fatty acids and inhibit excessive apoptosis of liver tissue cells, thereby improving lipid metabolism and preventing fatty liver.

Litchi chinensis Sonn  /  B-type proanthocyanidins trimer  /  steatosis of hepatocytes  /  molecular mechanism
Guang-Yi LUO, Ye-Jie WEN, Rui-Fen ZHANG, Mei DENG, Ming-Wei ZHANG, Xu-Chao JIA, Kun HU. Effects of B-type proanthocyanidins trimer from Litchi chinensis Sonn pulp on regulating lipid metabolism in hepatocytes[J]. Journal of Food Safety & Quality, 2025 , 16 (5) : 69 -75 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20241120002
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Year 2025 volume 16 Issue 5
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20241120002
  • Receive Date：2024-11-20
  • Online Date：2025-07-19
  • Published：2025-03-15
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  • Received：2024-11-20
Funding
Affiliations
    1. College of Food Science, Guangdong Pharmaceutical University, Zhongshan 528400, China
    2. Sericultural & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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