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Objective To investigate the potential of Cornus officinalis extract (COE) to repair skin damage caused by ultraviolet-B (UVB) exposure and to elucidate the underlying mechanisms involved. Methods By detecting the expression of UVB induced matrix metalloproteinases (MMPs) and pro-inflammatory cytokines in human keratinocytes cells (HaCaT), the photoprotective effect of COE was evaluated, and its antioxidant enzyme activity and collagen content were assessed. After exposure of mouse hairless skin to UVB radiation, extracts were applied topically and epidermal thickness, skin water content and collagen mRNA expression were determined. Results Under UVB irradiation (354.128 mJ/cm2), 1 mg/mL COE significantly enhanced antioxidant enzyme activity and significantly reduced the expression of pro-inflammatory cytokines prostaglandin E2, interleukin-1 α, and interleukin-6; simultaneously reduced the expression of MMPs; the collagen content significantly increased, with the expression levels of type I collagen and type III collagen proteins increasing by 13% and 75%, respectively. In addition, COE could alleviate the thickening of mouse skin epidermis and loss of collagen caused by UVB radiation. Meanwhile, COE treatment reduced the content of malondialdehyde (MDA) by 69%, and increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) by 27% and 234%, respectively. Analysis of mRNA expression in mouse epidermis showed that treatment with COE resulted in a decrease in mRNA expression levels of Mmp1a and Mmp3, while mRNA levels of Col1a1 and Col3a1 increased. Conclusion COE can improve skin damage caused by UVB radiation. This improvement was associated with increased activity of antioxidant enzymes in cells, as well as reduced expression of pro-inflammatory cytokines and MMPs. The aim of this study is to further investigate the photoprotective potential of Cornus officinalis against UVB induced skin damage through mouse and cell models, and elucidate its potential mechanisms, providing a theoretical basis for the treatment of skin diseases caused by UVB photoaging and the development of new drugs from Cornus officinalis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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