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Efficacy of throat lozenge concentrate in bacterial inflammation resolution based on the Danio rerio model
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Bai-Jian WU1, 2, 3, Zhi-Hong ZHU1, 3, Shao-Zhong PENG2, 3, Jia-Tao HE2, 3, Xiao-Dan HUANG2, 3, *
Journal of Food Safety & Quality | 2025, 16(10) : 318 - 324
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Journal of Food Safety & Quality | 2025, 16(10): 318-324
• Food Nutrition and Functional Foods •
Efficacy of throat lozenge concentrate in bacterial inflammation resolution based on the Danio rerio model
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Bai-Jian WU1, 2, 3, Zhi-Hong ZHU1, 3, Shao-Zhong PENG2, 3, Jia-Tao HE2, 3, Xiao-Dan HUANG2, 3, *
Affiliations
  • 1. Guangzhou Branch of Guangzhou Pharmaceutical Holdings Wanglaoji (Bijie) Industrial Company Limited, Guangzhou 510000, China
  • 2. Guangzhou Wanglaoji Pharmaceutical Co., Ltd., Guangzhou 510000, China
  • 3. Guangdong Key Laboratory of Famous and Excellent Traditional Chinese Patent Medicines and Simple Preparations and Herbal Tea Enterprises, Guangzhou 510000, China
Published: 2025-05-25 doi: 10.19812/j.cnki.jfsq11-5956/ts.20241203002
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Objective To investigate the efficacy of throat lozenge concentrate in promoting the resolution of bacterial inflammation. Methods Danio rerio model of lipopolysaccharide-induced bacterial inflammation was employed. In order to analyze the efficacy in bacterial inflammation resolution, the transgenic Danio rerio at 3-day post-fertilization was randomly selected for setting a normal control group, a model experimental group, a positive control group and throat lozenge concentrate (at the mass concentrations of 62.5, 125.0 and 250.0 μg/mL) dosage groups. Results Throat lozenge concentrate was found to reduce the amount of neutrophils, decrease the fluorescence intensity of macrophages, lower the nitric oxide fluorescence intensity at the inflammatory site, and downregulate the relative expression levels of cox2, myd88, erk2, nf-κb and tnf-α genes, while upregulating the relative expression level of the iκb-α gene. At a low mass concentration (62.5 µg/mL), the relative expression levels of inos and il-1β genes could be downregulated Conclusion The throat lozenge concentrate demonstrates efficacy in promoting the resolution of bacterial inflammation, thereby providing a scientific basis for its application in product development.

bacterial inflammation  /  throat lozenge concentrate  /  inflammation resolution  /  Danio rerio
Bai-Jian WU, Zhi-Hong ZHU, Shao-Zhong PENG, Jia-Tao HE, Xiao-Dan HUANG. Efficacy of throat lozenge concentrate in bacterial inflammation resolution based on the Danio rerio model[J]. Journal of Food Safety & Quality, 2025 , 16 (10) : 318 -324 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20241203002
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Year 2025 volume 16 Issue 10
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20241203002
  • Receive Date：2024-12-03
  • Online Date：2025-07-15
  • Published：2025-05-25
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  • Received：2024-12-03
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Affiliations
    1. Guangzhou Branch of Guangzhou Pharmaceutical Holdings Wanglaoji (Bijie) Industrial Company Limited, Guangzhou 510000, China
    2. Guangzhou Wanglaoji Pharmaceutical Co., Ltd., Guangzhou 510000, China
    3. Guangdong Key Laboratory of Famous and Excellent Traditional Chinese Patent Medicines and Simple Preparations and Herbal Tea Enterprises, Guangzhou 510000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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