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Objective To investigate the lipid-lowering and liver protective effects of β-nicotinamide mononucleotide (NMN) on hyperlipidemic model rats. Methods The 50 male SD rats were randomly divided into a normal group, a model group and low, medium and high dose groups of NMN (10, 50, 250 mg/kg), with 10 rats in each group. The normal group was given maintenance feed, while the other groups were given high-fat feed to establish a high-fat model. After successful modeling, gastric lavage intervention was performed in each group. After 5 weeks of intervention, serum biochemical indicators and blood lipids were measured, including total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c), high densitylipoprotein cholesterol (HDL-c) levels, glucose (GLU), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine (CREA) levels, combined with pathological observation of liver histological changes and nonalcoholic fattyliver disease activity score (NAS) of liver tissues was evaluated. Results Compared with the normal group, the body weight of the model group rats increased significantly, and the levels of TG, TC, LDL-c and ALT (P<0.01) in their serum increased significantly, AST and ALP levels significantly increased (P<0.05) The level of HDL-c (P<0.05) decreased significantly, while GLU and CREA showed no significant changes. Compared with the model group, the TG, TC and ALT levels in the low and medium dose groups were significantly reduced (P<0.05), the LDL-c in the medium dose group was significantly reduced (P<0.01). The TG, AST and ALT content in the high-dose group was significantly reduced (P<0.05). However, TC and LDL-c were significantly reduced (P<0.01); there was no significant difference in HDL-c, ALP, GLU and CREA. Compared with the model group, the low, medium, and high dose groups improved hepatic steatosis and inflammatory infiltration in rats, and the total score of NAS in the medium and high dose groups was reduced and showed statistical significance. Conclusion NMN can reduce the blood lipid levels in hyperlipidemic SD rats and has a certain protective effect on the liver.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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