Full
Outline
To explore the genomic characteristics and drug resistance of Salmonella Rissen in Yongchuan District, Chongqing from 2023 to 2025.
The 10 strains of foodborne Salmonella Rissen isolated in Yongchuan District, Chongqing City from 2023 to 2025 were identified, subjected to molecular identification, drug sensitivity tests and whole-genome sequencing. Based on sequencing data, molecular tracing and prediction of drug resistance genes were conducted.
The 10 strains of Salmonella Rissen had a resistance rate of 100.00% to tetracycline (TET), and the resistance rates to ampicillin (AMP), ampicillin/sulbactam (AMS), chloramphenicol (CHL),florfenicol (FFC) and trimethoprim/sulfamethoxazole (SXT) were greater than or equal to 50%, and all showed multi-drug resistance strains. All of the Salmonella Rissen carried a total of 94 drug resistance genes of 8 types. The prediction results of drug resistance genes were highly consistent with the drug resistance phenotype. A total of 9 virulence islands were carried. All isolates carried C63PI, SPI-1–3, SPI-5, SPI-8 and SPI-9 virulence islands.Phylogenetic analysis revealed that in this study, Salmonella Rissen was more closely related to the Eurasian branch, and there was clustering between the food strain and the case strain.
In Yongchuan District, the problem of drug resistance and multi-drug resistance of Salmonella Rissen in foodborne diseases is particularly prominent, the drug resistance phenotype is highly correlated with the genotype, and there is clustering between food isolates and human isolates. The quarantine of pathogenic bacteria and food hygiene education in the food trade and circulation links should be strengthened. Meanwhile, it is suggested to establish a whole-genome combined drug resistance analysis database of Salmonella in this region, strengthen gene monitoring and research on drug resistance mechanisms, achieve precise traceability of pathogenic bacteria, realize networked monitoring of pathogenic bacteria, thereby optimizing drug resistance prevention and control in the region, guiding clinical medication, and providing a scientific basis for achieving the health of the entire population.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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