Full
Outline
To establish an method for the determination of tamoxifen in solid drinks, liquid drinks,hard capsules, soft capsules and table candy by high performance liquid chromatography-tandem mass spectrometry.
The samples were extracted with 0.1% formic acid acetonitrile solution as ultrasonic extractant, and the analytical solution was purified by pass-through solid-phase extraction to detect tamoxifen in solid drinks, liquid drinks, hard capsules, soft capsules and tablet candy. Agilent Eclipse Plus RRHD C18 column (100 mm×2.1 mm,1.8 μm) was used for separation, electrospray negative ion mode, tandem mass spectrometry for detection, and external standard method for quantification.
That concentration of tamoxien was good linear relationship within the range of 1.0–100.0 ng/mL, and the correlation coefficient was above 0.999; the limit of detection was 0.015 mg/kg; The limit of quantitation was 0.050 mg/kg.
The method has been verified by the method with high sensitivity, good stability and simple operation, which can meet the requirements of precision and sensitivity for the detection of tamoxifen in solid drinks, liquid drinks, hard capsules, soft capsules and tablet candy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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