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Research progress on screening and optimization of nucleic acid aptamers applied in the field of food safety detection
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Guo-Chao CHEN1, 2, 3, Ying-Xue WANG2, 3, Ming-Wen YANG2, 3, Yu-Cheng JI2, 3, Bing-Huan HUANG2, 3, Guo-Chao CHEN1, 2, 3, Hui LIU2, 3, Hao LI1, 2, 3, *, Ying-Xue WANG2, 3, Ming-Wen YANG2, 3, Yu-Cheng JI2, 3, Bing-Huan HUANG2, 3, Hui LIU2, 3, Hao LI1, 2, 3, *
Journal of Food Safety & Quality | 2026, 17(16) : 227 - 235
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Journal of Food Safety & Quality | 2026, 17(16): 227-235
• Food Analysis and Detection •
Research progress on screening and optimization of nucleic acid aptamers applied in the field of food safety detection
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Guo-Chao CHEN1, 2, 3, Ying-Xue WANG2, 3, Ming-Wen YANG2, 3, Yu-Cheng JI2, 3, Bing-Huan HUANG2, 3, Guo-Chao CHEN1, 2, 3, Hui LIU2, 3, Hao LI1, 2, 3, *, Ying-Xue WANG2, 3, Ming-Wen YANG2, 3, Yu-Cheng JI2, 3, Bing-Huan HUANG2, 3, Hui LIU2, 3, Hao LI1, 2, 3, *
Affiliations
  • 2.School of Public Health, Jining Medical University, Jining 272067, China
  • 1.School of Public Health and Health Management, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji’nan 250117, China
  • 2.School of Public Health, Jining Medical University, Jining 272067, China
  • 3.Jining Key Laboratory of Food Nutrition and Safety, Jining 272067, China
  • 3.Jining Key Laboratory of Food Nutrition and Safety, Jining 272067, China
doi: 10.19812/j.cnki.jfsq11-5956/ts.20260225002
Outline
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Aptamer, as a single-stranded nucleic acid molecule screened by systematic evolution of ligands by exponential enrichment (SELEX), has shown broad application prospects in the field of food safety detection due to its advantages of high specificity, easy synthesis and modification and good stability. This paper reviewed the research progress of aptamer screening techniques for different target analytes (such as food-borne pathogens, microbial toxins, pesticides, heavy metal ions, etc.) in food safety detection, emphatically introduced the principles, characteristics and application scenarios of traditional SELEX (such as capture-SELEX, genomic-SELEX, capillary electrophoresis-SELEX, fluorescent‑magnetic-SELEX, real-SELEX, cell-SELEX, graphene oxide-SELEX). At the same time, this paper systematically expounded the mechanism of aptamer optimization strategy to improve the binding performance and detection applicability of aptamers, summarized the existing problems in the application of aptamers in food safety detection, introduced the current aptamer screening and optimization techniques and prospected their future development directions, providing a reference for the application of this technology in rapid and accurate detection of food safety.

nucleic acid aptamer  /  food safety detection  /  screening techniques  /  optimization strategy
陈国超, 王盈鳕, 杨茗雯, 季玉成, 黄秉奂, 刘辉, 李灏. 应用于食品安全检测领域核酸适配体筛选与优化的研究进展. 食品安全质量检测学报, 2026 , 17 (16) : 227 -235 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20260225002
Guo-Chao CHEN, Ying-Xue WANG, Ming-Wen YANG, Yu-Cheng JI, Bing-Huan HUANG, Hui LIU, Hao LI. Research progress on screening and optimization of nucleic acid aptamers applied in the field of food safety detection[J]. Journal of Food Safety & Quality, 2026 , 17 (16) : 227 -235 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20260225002
Appendix
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Year 2026 volume 17 Issue 16
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doi: 10.19812/j.cnki.jfsq11-5956/ts.20260225002
  • Receive Date：2026-02-25
  • Online Date：2026-11-05
Article Data
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  • Received：2026-02-25
Affiliations
    2.School of Public Health, Jining Medical University, Jining 272067, China
    1.School of Public Health and Health Management, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji’nan 250117, China
    2.School of Public Health, Jining Medical University, Jining 272067, China
    3.Jining Key Laboratory of Food Nutrition and Safety, Jining 272067, China
    3.Jining Key Laboratory of Food Nutrition and Safety, Jining 272067, China
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表12种不同金属材料的力学参数
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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