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Research progress of nutrient reference materials
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Ling-Wen HU1, 2, Dan SONG1, 2, Ying KAN1, 2, Xian-Jiang LI1, 2, Hong-Mei LI3, *, Sheng WANG1, 2, *
Journal of Food Safety & Quality | 2026, 17(6) : 167 - 177
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Journal of Food Safety & Quality | 2026, 17(6): 167-177
• Food Nutrition and Functional Foods •
Research progress of nutrient reference materials
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Ling-Wen HU1, 2, Dan SONG1, 2, Ying KAN1, 2, Xian-Jiang LI1, 2, Hong-Mei LI3, *, Sheng WANG1, 2, *
Affiliations
  • 1.Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing 100029, China
  • 2.Key Laboratory of Nutrition and Health Chemical Metrology and Application, State Administration for Market Regulation, Beijing 100029, China
  • 3.College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251210005
Outline
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Nutrient reference materials serve as fundamental substances for the determination and quality control of food nutritional components. They are essential tools for ensuring the scientific validity and regulatory compliance of food nutrition labeling, as well as advancing precision nutrition research. This paper systematically reviewed the development progress of nutrient reference materials both China and internationally. Existing studies indicate that China has established the world’s largest repository of nutrient reference materials, currently comprising more than 700 reference materials that cover major nutrient components such as proteins, lipids, carbohydrates, vitamins and elements. This had gradually formed a comprehensive system spanning from high purity reference materials to complex food-matrix reference materials. However, compared with internationally advanced standard, China still faced shortcomings in the balance of nutrient categories and diversity of matrix distributions, the development of reference materials with multi-nutrient characteristic quantities, and the characterization of structurally complex nutrients. Based on global trends in nutrition and health research and the urgent need for metrological support within China’s nutrition and health industry, this review aimed to provide theoretical guidance and practical insights for building a more comprehensive, scientifically robust and internationally influential nutrient reference material system.

nutrient  /  reference materials  /  food matrix  /  precision nutrition
胡凌雯, 宋丹, 阚莹, 李先江, 李红梅, 王晟. 营养素标准物质研究进展. 食品安全质量检测学报, 2026 , 17 (6) : 167 -177 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251210005
Ling-Wen HU, Dan SONG, Ying KAN, Xian-Jiang LI, Hong-Mei LI, Sheng WANG. Research progress of nutrient reference materials[J]. Journal of Food Safety & Quality, 2026 , 17 (6) : 167 -177 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251210005
Year 2026 volume 17 Issue 6
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2
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doi: 10.19812/j.cnki.jfsq11-5956/ts.20251210005
  • Receive Date:2025-12-10
  • Online Date:2026-11-05
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  • Received:2025-12-10
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Affiliations
    1.Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing 100029, China
    2.Key Laboratory of Nutrition and Health Chemical Metrology and Application, State Administration for Market Regulation, Beijing 100029, China
    3.College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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