Full
Outline
To investigate the in vivo antioxidant effects of balenine and its impact on skeletal muscle metabolism–related indicators, and its biosafety within the experimental dose range.
Mice were used as the experimental subjects and were administered different doses of balenine by gavage for 4 consecutive weeks.Physiological changes were monitored throughout the study, including body weight and the weights of major organs such as the liver, kidney and spleen. Hematoxylin-eosin staining was performed to evaluate tissue morphology.Antioxidant capacity was assessed by measuring malondialdehyde levels as well as the activities of catalase, total superoxide dismutase and glutathione peroxidase. The expression levels of 4 kinds of myosin heavy chain subtypes and genes related to energy metabolism were assessed using real-time quantitative reverse transcription polymerase chain reaction to evaluate skeletal muscle metabolic function.
Compared with the control group, balenine administration at all tested doses did not induce significant changes in body weight or major organ weights. Tissue structures remained intact without observable pathological lesions. Low-dose balenine significantly reduced the level of the lipid peroxidation product malondialdehyde and increased catalase and glutathione peroxidase activities.Meanwhile, low-dose balenine upregulated the expression of myosin heavy chain IIa and peroxisome proliferator-activated receptor-γ coactivator-1α.
Within the experimental dose range, balenine exhibits good biosafety, effectively improves the in vivo antioxidant status, and exerts positive regulatory effects on skeletal muscle metabolism and muscle fiber-type-related indicators. These findings provide scientific support for the potential use of balenine as a functional food ingredient.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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