Full
Outline
To evaluate the hypoxia tolerance activity and mechanisms of action of a compound formulation consisting of Olea europaea fruit-Lycium barbarum-Panax quinquefolius compound (Olea europaea fruit polyphenols:Lycium barbarum extract:Panax quinquefolius extract 5:5:1, m:m:m).
BALB/C mice were orally administered the compound for 30 consecutive days. Hypoxia tolerance was assessed using a normobaric hypoxia test (referencing Health food functional evaluation methods, 2023 edition) to determine survival time. The hypoxia tolerance mechanism was investigated by analyzing lactate dehydrogenase (LDH) activity, malondialdehyde(MDA) content and superoxide dismutase (SOD) levels in brain and lung tissues.
The Olea europaea fruit-Lycium barbarum-Panax quinquefolius compound significantly prolonged hypoxia survival time in mice [low,medium and high dose groups: (30.35±5.63), (37.53±6.72) and (39.13±8.73) min, respectively, significantly outperformed the control group (22.91±1.61) min; P<0.05 or P<0.001], and the effect was dose-dependent. Its effect was superior to that of the positive controls [Rhodiola oral solution: (26.50±2.44) min; Hongyi capsules:(28.93±6.67) min]. The mechanism was that it reduced LDH activity (reducing anaerobic metabolism) and MDA content (inhibiting lipid peroxidation), and increased SOD activity (enhancing free radical scavenging ability) in brain and lung tissues.
The Olea europaea fruit-Lycium barbarum-Panax quinquefolius compound exerts hypoxia tolerance effects by modulating oxidative stress pathways, including free radical scavenging, lipid peroxidation inhibition and antioxidant enzyme activity maintenance, and thus possesses the potential to be developed as a functional food.
8
2
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
