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Determination of residual levels of tildipirosin in raw milk by high performance liquid chromatography tandem mass spectrometry
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Mo LI1, 2, Zheng LV1, 2, Ting ZHOU2, Chun-Ming WANG1, 2, Qian WANG2, Jing-Jian JIA1, 2, Ke-Jing LI1, 2, *, Tao PENG1, 2, *
Journal of Food Safety & Quality | 2026, 17(6) : 280 - 286
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Journal of Food Safety & Quality | 2026, 17(6): 280-286
• Food Analysis and Detection •
Determination of residual levels of tildipirosin in raw milk by high performance liquid chromatography tandem mass spectrometry
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Mo LI1, 2, Zheng LV1, 2, Ting ZHOU2, Chun-Ming WANG1, 2, Qian WANG2, Jing-Jian JIA1, 2, Ke-Jing LI1, 2, *, Tao PENG1, 2, *
Affiliations
  • 1.CAIQ (Beijing) Testing and Certification Co., Ltd., Beijing 100176, China
  • 2.China Academy of Quality Inspection and Testing, Beijing 100176, China
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251126002
Outline
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Objective

To establish an analytical method for detection of residual tildipirosin in raw milk by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).

Methods

The sample was extracted with acid acetonitrile, purified by enhanced matrix removal (EMR) purification column, and then separated by BEH C18. The target compound was analyzed by a positive electrospray ion multiple reaction monitoring mode and quantitative analysis using matrix matching isotope internal standard method for quantification.

Results

The calibration curves were linear in the range of 2.5–100.0 ng/mL with correlation coefficients more than 0.99. The limit of detection was 2.5 μg/kg, limit of quantitation was 5.0 μg/kg. The average recoveries at different addition concentrations ranged from 78.2% to 97.6%, with the relative stand deviations of the determination results ranged from 6.02% to 7.69%.

Conclusion

This method is accuracy, sensitive stability, simple and easy to operate, which can be used to determinate of residual amounts of tildipirosin in raw milk.

tildipirosin  /  high performance liquid chromatography-tandem mass spectrometry  /  purification column  /  raw milk
李默, 吕铮, 周婷, 汪春明, 王倩, 贾景健, 李克静, 彭涛. 高效液相色谱-串联质谱法测定生牛乳中泰地罗新残留量. 食品安全质量检测学报, 2026 , 17 (6) : 280 -286 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251126002
Mo LI, Zheng LV, Ting ZHOU, Chun-Ming WANG, Qian WANG, Jing-Jian JIA, Ke-Jing LI, Tao PENG. Determination of residual levels of tildipirosin in raw milk by high performance liquid chromatography tandem mass spectrometry[J]. Journal of Food Safety & Quality, 2026 , 17 (6) : 280 -286 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20251126002
Appendix
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Year 2026 volume 17 Issue 6
12
2
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20251126002
  • Receive Date：2025-11-26
  • Online Date：2026-11-05
Article Data
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History
  • Received：2025-11-26
Funding
Affiliations
    1.CAIQ (Beijing) Testing and Certification Co., Ltd., Beijing 100176, China
    2.China Academy of Quality Inspection and Testing, Beijing 100176, China
References
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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