Full
Outline
Human milk oligosaccharides (HMOs) as an important functional component in breast milk, play an irreplaceable role in the nutrition and health of infants and young children. With the deepening understanding of its biological functions and the growth of market demand, the development of efficient, economical and sustainable HMOs separation and purification technologies and their alternatives has become a research hotspot. This article systematically reviewed the structural classification, biological functions and efficient separation and purification technologies of HMOs, including the advantages and limitations of chromatographic separation technologies such as gel filtration, ion exchange and simulated moving beds, membrane separation techniques such as ultrafiltration,nanofiltration and membrane integration processes, as well as purification and separation technologies such as solvent precipitation/extraction, activated carbon adsorption and electrophoresis. Meanwhile, this article also reviewed the research progress of HMOs alternative development methods, such as microbial fermentation, enzymatic synthesis,chemical synthesis and new biomanufacturing technologies. Through quantitative comparison, it provided a reference for technology selection, and prospected the future research directions, with the aim of providing references for the large-scale and low-cost development of the HMOs industry and promoting its wide application in the fields of infant nutrition and medical care.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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