Full
Outline
To investigate the alcohol detoxification and hepatoprotection effects of fermented Pueraria lobata-Hovenia dulcis compound paste (FPHCP) on mice with alcoholic liver injury.
A drunkenness model was established by intragastrically administering 50% vol Hongxing Erguotou to C57BL/6 mice for 30 consecutive days. Meanwhile, the mice were given intragastric administration of the positive drug (silybin) and FPHCP at low, medium and high dose levels (3.08, 6.15, 12.30 g/kg) daily. The effects of FPHCP on the basic physiological activities, drunkenness time and sobering-up time of the mice were observed. The liver, spleen and kidney indices of the mice, as well as the levels of liver injury markers, lipid metabolism indicators, oxidative stress-related factors and inflammatory factors in serum and liver tissue were detected. Additionally, pathological analysis of liver tissue sections was performed to evaluate the alcohol detoxification and hepatoprotection efficacy of FPHCP.
FPHCP intervention effectively delayed the trend of weight loss in C57BL/6 mice, significantly prolonged the alcohol tolerance latency (P<0.01), and simultaneously significantly shortened the recovery time of motor coordination function and the duration of loss of righting reflex (P<0.01). Compared with the model group, the FPHCP groups significantly adjusted the liver and spleen indices back to normal levels (P<0.01), increased the activity of antioxidant enzymes, reduced the level of oxidative stress and lipid metabolism disorder, decreased the inflammatory response of the body, and alleviated liver vacuolar degeneration, inflammatory infiltration and lipid deposition.
As a functional food, FPHCP has good application potential in the field of alcohol detoxification and hepatoprotection.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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