To comprehensively understand the source, characteristics, poisoning mechanism, detection methods,standards and regulations, and distribution in different honeys of grayanotoxins (GTXs) in honey, this paper performed a comparative analysis on the following aspects: The botanical origins of GTXs in honey; their chemical structures and fragmentation pathways in mass spectrometry; their concentration distributions across various honey types; the toxicological mechanisms and potential pharmacological activities of GTXs; the differences in detection methods for GTXs in honey; and the current relevant standards and regulations established by different countries.Through reviewing the literature on GTXs in honey, it is found that the regulation of GTXs in honey is currently insufficient, commercial GTXs standards are scarce, and the number of toxins covered by existing detection methods is limited. This review is intended to serve as a reference for understanding the characteristics of GTXs, assessing their distribution in different honeys, improving public health safety, and promoting the commercialization of more GTXs reference standards and the development of related regulations.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |