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Interaction characteristics between gut microbiota from patients with perimenopausal syndrome and flavonoids in the in vitro gastrointestinal simulation system of Dandouchi
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Jing LI1, Min-Ai ZHANG2, Hai-Li WANG3, Hui-Ling HU4, Xi-Chun ZHANG1, *, Ji-Quan LIU1, *
Journal of Food Safety & Quality | 2026, 17(3) : 229 - 238
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Journal of Food Safety & Quality | 2026, 17(3): 229-238
• Food Nutrition and Functional Foods •
Interaction characteristics between gut microbiota from patients with perimenopausal syndrome and flavonoids in the in vitro gastrointestinal simulation system of Dandouchi
Full
Jing LI1, Min-Ai ZHANG2, Hai-Li WANG3, Hui-Ling HU4, Xi-Chun ZHANG1, *, Ji-Quan LIU1, *
Affiliations
  • 1.School of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030619, China
  • 2.Taiyuan Customs Technology Center, Taiyuan 030021, China
  • 3.Wenshui County Hospital of Traditional Chinese Medicine, Lvliang 032199, China
  • 4.Changzhi Hospital of Traditional Chinese Medicine, Shanxi Province, Changzhi 046013, China
doi: 10.19812/j.cnki.jfsq11-5956/ts.20250907001
Outline
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Objective

To investigate the interaction mechanism between flavonoids in dietary Dandouchi and intestinal microbiota.

Methods

This study employed an in vitro whole-biome gastrointestinal simulation system, with 16S rDNA sequencing for microbiota profiling, and high performance liquid chromatography-tandem triple quadrupole mass spectrometry for flavonoid metabolic transformation analysis. Finally, Spearman correlation analysis was used to analyze the correlation between the two.

Results

Demonstrated that dietary Dandouchi significantly improved intestinal microbiota composition, increasing probiotic Bacteroides from 0.73% to 3.61% and Ruminiclostridium_9 from 0.20% to 0.94%, while reducing pathogenic Escherichia-Shigella from 17.59% to 11.39%.Regarding flavonoid metabolism, intestinal microbiota mediated an reduction in glycoside-type flavonoids (e.g., daidzin, glycitin) and a more pronounced decrease in aglycone-type flavonoids (e.g., butein, daidzein) (P<0.05). Correlation analysis revealed significant negative associations between Bacteroides and daidzin, and positive correlations between Parasutterella and naringenin (P<0.05).

Conclusion

Dietary Dandouchi modulates specific microbiota (e.g., Bacteroides, Parasutterella) to enhance flavonoid biotransformation, thereby improving bioactivity, providing a theoretical foundation for developing dietary Dandouchi-based microecological regulators.

dietary Dandouchi  /  flavonoids  /  intestinal microbiota  /  16S rDNA sequencing  /  high performance liquid chromatography-tandem triple quadrupole mass spectrometry
李静, 张敏爱, 王海丽, 胡会玲, 张希春, 刘计权. 淡豆豉体外胃肠模拟体系中围绝经期综合征患者肠道菌群与类黄酮的互作特征. 食品安全质量检测学报, 2026 , 17 (3) : 229 -238 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20250907001
Jing LI, Min-Ai ZHANG, Hai-Li WANG, Hui-Ling HU, Xi-Chun ZHANG, Ji-Quan LIU. Interaction characteristics between gut microbiota from patients with perimenopausal syndrome and flavonoids in the in vitro gastrointestinal simulation system of Dandouchi[J]. Journal of Food Safety & Quality, 2026 , 17 (3) : 229 -238 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20250907001
Appendix
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Year 2026 volume 17 Issue 3
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Article Info
doi: 10.19812/j.cnki.jfsq11-5956/ts.20250907001
  • Receive Date：2024-09-07
  • Online Date：2026-11-05
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  • Received：2024-09-07
Funding
Affiliations
    1.School of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030619, China
    2.Taiyuan Customs Technology Center, Taiyuan 030021, China
    3.Wenshui County Hospital of Traditional Chinese Medicine, Lvliang 032199, China
    4.Changzhi Hospital of Traditional Chinese Medicine, Shanxi Province, Changzhi 046013, China
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https://castjournals.cast.org.cn/joweb/spaq/EN/10.19812/j.cnki.jfsq11-5956/ts.20250907001
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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