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Fabrication and characterization of quercetin loaded with soy protein isolates/fucoidan composite nanoparticles
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Meng-Li LU1, 2, 3, Tao-Hong ZHOU1, 2, 3, Jin LIN1, 2, 3, Yun YOU1, 2, 3, Xin-Yuan LI4, Rui ZHOU1, 2, 3, Li CHEN1, 2, 3, Shi-Yao LI1, 2, 3, Li ZHANG1, 2, 3, *
Journal of Food Safety & Quality | 2026, 17(7) : 73 - 81
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Journal of Food Safety & Quality | 2026, 17(7): 73-81
• Highlight: Hubei Provincial Institute for Food Supervision and Test •
Fabrication and characterization of quercetin loaded with soy protein isolates/fucoidan composite nanoparticles
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Meng-Li LU1, 2, 3, Tao-Hong ZHOU1, 2, 3, Jin LIN1, 2, 3, Yun YOU1, 2, 3, Xin-Yuan LI4, Rui ZHOU1, 2, 3, Li CHEN1, 2, 3, Shi-Yao LI1, 2, 3, Li ZHANG1, 2, 3, *
Affiliations
  • 1.Hubei Provincial Institute for Food Supervision and Test, Wuhan 430075, China
  • 2.Key Laboratory of Detection Technology of Focus Chemical Hazards in Animal-derived Food, State Administration for Market Regulation, Wuhan 430075, China
  • 3.Hubei Shizhen Laboratory, Wuhan 430065, China
  • 4.Center for Drug Evaluation and Inspection of HMPA (Hubei Center for Vaccine Inspection), Wuhan 430071, China
doi: 10.19812/j.cnki.jfsq11-5956/ts.20250905002
Outline
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Objective

To construct a delivery system loaded with quercetin (QT), enhance QT’s solubility and stability.

Methods

This study used soy protein isolates (SPI) and fucoidan (Fuc) as raw materials, and constructed composite nanoparticles using the pH-driven method to encapsulate QT. The different quality ratios of SPI-QT-Fuc composite nanoparticles (SQF NPs) were evaluated based on particle size, potential, loading rate, embedding rate, freeze-drying reconstitution properties and microscopic morphology. The physicochemical properties of SQF NPs were analyzed using fluorescence spectroscopy and Fourier transform infrared spectroscopy. The stability changes of SQF NPs under different environmental conditions (temperature, light, salt concentration, pH and storage time) were investigated to simulate gastrointestinal digestion and evaluate the gastrointestinal stability and bioavailability of SQF NPs.

Results

The particle size of composite nanoparticles was (130.60±1.03) nm, the potential was(–33.14±2.35) mV, and the encapsulation rate reached 80.05% when the SPI/Fuc/QT mass ratio was 10:2:1. The binding forces of composite nanoparticles with uniform size distribution were the interplay of hydrogen bonds, hydrophobic interactions, and electrostatic forces. Compared to free QT, composite nanoparticles significantly enhanced the solubility, photothermal stability and gastrointestinal utilization of QT.

Conclusion

The composite nanoparticles, built upon SPI and Fuc, significantly improves the solubility, stability of QT, and will provide a promising avenue for the efficient application of QT in the food industry.

soy protein isolates  /  fucoidan  /  quercetin  /  pH-driven method  /  composite nanoparticles
鲁孟丽, 周陶鸿, 林津, 游云, 李心愿, 周蕊, 陈锂, 李诗瑶, 张莉. 负载槲皮素的大豆分离蛋白/岩藻多糖复合纳米颗粒的制备及表征. 食品安全质量检测学报, 2026 , 17 (7) : 73 -81 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20250905002
Meng-Li LU, Tao-Hong ZHOU, Jin LIN, Yun YOU, Xin-Yuan LI, Rui ZHOU, Li CHEN, Shi-Yao LI, Li ZHANG. Fabrication and characterization of quercetin loaded with soy protein isolates/fucoidan composite nanoparticles[J]. Journal of Food Safety & Quality, 2026 , 17 (7) : 73 -81 . DOI: 10.19812/j.cnki.jfsq11-5956/ts.20250905002
Appendix
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Year 2026 volume 17 Issue 7
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doi: 10.19812/j.cnki.jfsq11-5956/ts.20250905002
  • Receive Date：2025-09-05
  • Online Date：2026-11-05
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History
  • Received：2025-09-05
Funding
Affiliations
    1.Hubei Provincial Institute for Food Supervision and Test, Wuhan 430075, China
    2.Key Laboratory of Detection Technology of Focus Chemical Hazards in Animal-derived Food, State Administration for Market Regulation, Wuhan 430075, China
    3.Hubei Shizhen Laboratory, Wuhan 430065, China
    4.Center for Drug Evaluation and Inspection of HMPA (Hubei Center for Vaccine Inspection), Wuhan 430071, China
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https://castjournals.cast.org.cn/joweb/spaq/EN/10.19812/j.cnki.jfsq11-5956/ts.20250905002
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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