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Objective To analyze the molecular epidemiological characteristics, virulence gene profiles, and distribution of antibiotic resistance genes of Vibrio parahaemolyticus (VP) isolated from foodborne diseases patients in Dalian City, Liaoning Province. Methods A total of 63 VP clinical isolates were collected from Dalian City in 2023. The whole genome sequencing, multilocus sequence typing, virulence genes and drug resistance genes were analyzed, and the clinical epidemiological data were combined for comprehensive analysis. Results July-September was the main epidemic period of VP. The results of sequence type (ST) showed that ST3 was the main epidemic group. The 63 strains carried both tlh and vcrD, and the carrying rate of tdh and vcrD2 virulence genes was 95.24%. All strains carried blaCARB-47, CARB-20, tet (35), tet (34) and CRP resistance genes, and one ST3 strain also carried aminoglycosides, sulfonamides and other resistance genes. There was a certain correlation between virulence gene carrying type and ST type, but there was no obvious clustering feature in the distribution of drug resistance genes. All isolates from patients with systemic symptoms carried tdh and vcrD2. Conclusion ST3 is the main epidemic group of VP in Dalian, Liaoning Province, which is widely distributed and has a high proportion of virulence genes. Speical attention should be paid to the risk of drug resistance transmission of ST3. This study provides a molecular epidemiological basis for the prevention and control of VP.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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