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Objective To evaluate the safety of a composite beverage made from Ganoderma leucocontextum fermented Pu-erh tea compound beverage. Methods Using the Ganoderma leucocontextum fermented Pu-erh tea compound beverage as the study subject, based on preliminary experiments and related research, the dose was set at 10000 mg/(kg·bw). The classical limit method was employed, with healthy ICR mice selected as the experimental model, and the test substance was administered via oral gavage. The experiment strictly adhered to animal ethics and welfare principles, with precise control of environmental conditions including temperature, humidity and light cycles to ensure the accuracy and reliability of the data. Results After administration of the test substance, no signs of toxicity were observed in any of the ICR mice throughout the observation period. Their behavioral activity remained normal, with glossy fur and vigorous spirits. Regular precise measurements of mouse body weight showed no significant abnormalities in growth trends, and no deaths occurred. Statistical analysis revealed that the acute oral toxicity median lethal dose (LD50) values for both male and female ICR mice were greater than 10000 mg/(kg·bw), with 95% confidence intervals also exceeding 10000 mg/(kg·bw). Conclusion Based on international acute toxicity dose classification standards, the Ganoderma leucocontextum fermented Pu-erh tea compound beverage is classified as practically non-toxic. This indicates that under the experimental conditions of this study, the acute oral intake safety of this composite beverage is high, providing critical safety data support for subsequent product development and market promotion.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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