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Objective To understand the drug resistance phenotypes,, carriage of drug resistance genes and virulence genes, serotypes and sequence type (ST) classification of Campylobacter jejuni in Xuzhou from 2023 to 2024. Methods Whole genome sequencing was conducted on Campylobacter jejuni isolated from Xuzhou City in 2023—2024 to understand the molecular characteristics such as virulence genes, drug resistance genes, and multilocus sequence typing. The serotypes related to Guillain-Barré syndrome were identified by real-time fluorescent quantitative polymerase chain reaction (PCR), and the drug resistance phenotypes were determined by agar dilution method. Results Forty-eight strains of Campylobacter jejuni were classified into 24 ST types. ST137 was the most numerous, accounted for 18.75% (9/48). Fifteen strains were found to have serotypes related to Guillain-Barré syndrome. A total of 24 drug resistance genes and 121 virulence genes were detected. The top 3 antibiotics with the highest resistance rates were nalidixic acid (100.00%), ciprofloxacin (100.00%), and tetracycline (97.92%). They were 100.0% sensitive to erythromycin, and the multi-drug resistance rate reached 62.50% (30/48). Conclusion Campylobacter jejuni in Xuzhou area is characterized by a high rate of multi-drug resistance, a relatively high carrying rate of some drug resistance genes, a high carrying rate of virulence genes, a large number of sequence types (ST types), and shows relatively high genetic diversity.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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