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Objective To establish a method for the determination of 11 kinds of residues of benzimidazole drugs in freshwater fish and shrimp by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Methods The samples were first extracted by acetonitrile twice, purified by mixed strong cationic solid phase extraction column, then separated by Waters C18 column, detected by UPLC-MS/MS, and the internal standard method was adopted for quantitative analysis. Results The 11 kinds of benzimidazole drugs showed good linear relationships at 1.0-50.0 μg/L, with correlation coefficients (r2) greater than 0.99. The ranges of spiked recovery rates for 3 concentrations of blank fish samples were between 78.4% and 104.3%, and the relative standard deviations of the recovery rates for 3 concentrations were between 2.0% and 8.8%; the recovery rates of 3 concentrations of shrimp meat blank samples ranged from 73.3% to 107.5%, with relative standard deviations between 1.5% and 8.7%. The limit of detection of the method in this study was 0.5 μg/kg, and the limit of quantification of the method was 2.0 μg/kg. Conclusion The method has good purification effect, stable reproducibility and recovery, and is suitable for the determination of 11 kinds of benzimidazole residues in freshwater fish and shrimp.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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