With the vacuum formed and coated instrument panel of a vehicle as the research object, this article, through experimental analysis, indicated that the instrument panel blistered, and triggered the blistering condition after the vehicle was exposed to a high temperature of more than 100 ℃ for 30 minutes continuously. The research focused on enhancing the bonding strength of glue and skeleton as countermeasure. Through research, the bonding strength can be enhanced by adjusting the mold gap, enhancing the exhaust property of the skeleton, and increasing the roughness of the skeleton, so as to eliminate blistering. The article also pointed out that adding the oven with temperature of 100 ℃ for 30 min as a quality control procedure can effectively prevent the blistering and defective products from flowing out of the production line, and provide a reference for solving the problem of blistering in the vacuum forming coating process.