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Meta Analysis of the Correlation between Aerobic Exercise and Cardiac Function, Lipid Metabolism, and Inflammation in Patients with Cardiovascular Disease
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Guo-dong ZHANG1, Si-ang WEI2, 3, Jin-xia GAO4, Hui HE1, Feng PAN4, Yan-li XIE1, *
Science Technology and Engineering | 2025, 25(9) : 3604 - 3612
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Science Technology and Engineering | 2025, 25(9): 3604-3612
• Papers·Medicine •
Meta Analysis of the Correlation between Aerobic Exercise and Cardiac Function, Lipid Metabolism, and Inflammation in Patients with Cardiovascular Disease
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Guo-dong ZHANG1, Si-ang WEI2, 3, Jin-xia GAO4, Hui HE1, Feng PAN4, Yan-li XIE1, *
Affiliations
  • 1 Department of Physical Education, Shanxi Agricultural University, Taigu 030801, China
  • 2 College of Life Sciences, Shanxi Agricultural University, Taigu 030801, China
  • 3 Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China
  • 4 College of Physical Education, Sichuan University, Chengdu 610065, China
Published: 2025-03-28 doi: 10.12404/j.issn.1671-1815.2400817
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To investigate the correlation between aerobic exercise and cardiac function, lipid metabolism, and inflammation in patients with cardiovascular disease, by searching PubMed, Embase, Scopus, and China National Knowledge Infrastructure (CNKI) databases for relevant studies on the effects of aerobic exercise on cardiac function, lipid metabolism, and inflammatory factors in patients with cardiovascular disease, Meta-analysis and correlation analysis were conducted using RevMan5.4 and R software. The results show that aerobic exercise significantly reduces B-type natriuretic peptide (BNP) [SMD=-0.84, 95% CI (-1.34, - 0.34), P=0.001], systolic blood pressure (SBP) [SMD=- 0.55, 95% CI (-0.86, - 0.25), P=0.000 4], and diastolic blood pressure (DBP) [SMD=- 0.99, 95% CI (-1.67, - 0.32), P=0.004], LDL [SMD=- 0.53, 95% CI (- 0.89, - 0.18), P=0.003], and C-reactive protein (CRP) [SMD=-0.53, 95% CI (-0.90, -0.16), P=0.005]. CRP is positively correlated with HDL, LDL, and DBP, with correlation coefficients of 0.35, 0.26, and 0.28, respectively. CRP is negatively correlated with SBP, with correlation coefficients of -0.31. From this, it can be seen that aerobic exercise can improve heart function, lipid metabolism, and levels of inflammatory factors to a certain extent in patients with cardiovascular diseases, and there is a correlation between heart function, lipid metabolism, and inflammation.

aerobic exercise  /  cardiovascular disease  /  cardiac function  /  lipid metabolism  /  inflammation  /  C-reactive protein  /  correlation analysis
Guo-dong ZHANG, Si-ang WEI, Jin-xia GAO, Hui HE, Feng PAN, Yan-li XIE. Meta Analysis of the Correlation between Aerobic Exercise and Cardiac Function, Lipid Metabolism, and Inflammation in Patients with Cardiovascular Disease[J]. Science Technology and Engineering, 2025 , 25 (9) : 3604 -3612 . DOI: 10.12404/j.issn.1671-1815.2400817
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Year 2025 volume 25 Issue 9
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Article Info
doi: 10.12404/j.issn.1671-1815.2400817
  • Receive Date：2024-01-28
  • Online Date：2025-07-09
  • Published：2025-03-28
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History
  • Received：2024-01-28
  • Revised：2024-12-04
Funding
Affiliations
    1 Department of Physical Education, Shanxi Agricultural University, Taigu 030801, China
    2 College of Life Sciences, Shanxi Agricultural University, Taigu 030801, China
    3 Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China
    4 College of Physical Education, Sichuan University, Chengdu 610065, China
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