In order to study the applicability of the assembled subway station structure in the liquefiable site of the seismic fortification area, based on the engineering practice of Shuangfeng Station of Changchun Metro, the seismic response analysis of the assembled subway station structure in the liquefiable stratum was carried out by using the finite difference software FLAC^3D. Compared with the calculation results of the corresponding cast-in-place subway station conditions, the pore water pressure of the foundation, the dynamic response and floating characteristics of the subway station structure and the deformation characteristics of the assembled subway station structure were studied. The results show that, similar to the calculation condition of cast-in-place underground structure, in the calculation condition of assembled subway station in liquefiable site, the pore pressure ratio of site soil shows three stages: initial slow increase stage, middle rapid increase stage and final gentle stage. When the seismic intensity is high, the underground structure has a significant inhibitory effect on the liquefaction of the surrounding soil. The acceleration response of the prefabricated station structure is smaller than that of the cast-in-place structure, which reflects its flexible adaptation to the deformation of the terrain in the liquefiable site. The connection between the side wall and the middle plate is the key part of structural strength control. When the intensity of the input ground motion is low, the vertical displacement changes of the structure are manifested at different positions of the bottom plate show the development stage of a small amount of sinking at the beginning, then a sharp rise, and finally a downward trend, but with the increase of the intensity of the ground motion, this phenomenon is gradually not obvious. The deformation of the assembled subway station structure under horizontal ground motion is closer to the shear deformation. Its flexible connection is easier to adapt to the larger vertical relative deformation than the rigid connection of the cast-in-place station, and its anti-overturning ability is better.