In order to study the effect of freeze-thaw cycle on the stability of lime-amended loess slope, the change rule of shear strength and soil-water characteristics of lime-amended loess under different numbers of freeze-thaw cycles was obtained by straight shear test and soil-water characteristics test, and the stability of high-fill loess slope was analysed by using the strength discount method with MIDAS GTS NX software. The results show that: the internal friction angle and cohesion of the soil samples both increase with the increase of the age of maintenance, and with the increase of the number of freeze-thaw cycles, the internal friction angle of the soil samples will first increase and then gradually tend to be stable, and the cohesion will first decrease and then gradually tend to be stable; the lime-amended loess has its matrix suction maximum at the lowest temperature of the first freeze-thaw cycle, and its matrix suction is minimum at the second freeze-thaw cycle, and after that the matrix suction of the soil body increased. Freezing and thawing cycles will cause the slope infiltration flow rate to increase; the trend of pore water pressure changes in the freezing and thawing slope model is the same as that of the unfrozen slope, and the pore water pressure is positive at the bottom of the slope model, and then decreases gradually near the top of the slope, and then reaches the minimum at the top of the slope. The freeze-thaw cycle will cause the strain of the slope to increase under rainfall conditions, which affects the safety and stability of the slope; the shallow freeze-thaw has little effect on the safety of high-fill improved loess slopes.