Worksheet is an important learning intervention tool in science education institutes. By carrying out a research in the Nature Exhibition Area at Shanghai Natural History Museum, this study applied the contextual model of learning to analyze, evaluate and redesign worksheets of the exhibition. The research team then conducted the quasi-experiment, which was intended to capture the effect of 3 worksheets on family learning in museum setting. The results show that in the alive animal exhibition: (1) Families without worksheet can proactivly use prior knowledge and life experience to interact closely, but they lacked self-confidence in their own conclusion. (2) Using worksheet that is against the model reduced the family visit time and the number of all types of learning talk. (3) Using worksheets that embody the model helped families to confidently build a more reasonable understanding of the exhibits from multiple perspectives. The natural history museum can display terrarium of alive animals to enrich the exhibition. Contextual model of learning is proved to be an effective model to guide the design and using process of worksheet.