The use of comics as an easy way to display and disseminate obscure scientific and technological knowledge can be well accepted and loved by the public. However, it is not appropriate to simply use the new formulation of popular animation or animation and popular science, because popular science itself is typographically labeled, which allows anime lovers to easily filter out related works during reading, affecting the effect of the work. At present, the integration among creation works in China mainly focuses on the level of one-way integration and mutual benefit, and the interest and fun is still lingering at a lower level. If we want to create a level of integration and integration of works, there is a contradiction between the popularization of animation and popular science positioning, for example, the aesthetic flavor of science and animation is not at the same level, the reader's reading pleasure is easily affected by the popular science education, simply, the superstitious ability of excellent cartoon works can not fundamentally solve the problem of poor quality of popular science, and the science element is not suitable for its commercialization. Therefore, we must face up to the inherent contradiction in the integration of animation and science. In the creation, we must concentrate on improving the level of the animation story script. The science knowledge should be integrated into the daily life, and then be integrated into the story script creation, so that a highly integrated animation and science popularization excellent work can be produced.