From the perspective of serving the construction of scientific and technological powerhouse，this paper analyzes the development of China’s science and technology popularization since the implementation of the Law of the People’s Republic of China on Popularization of Science and Technology. It discusses the opportunities and challenges it faces in the new era，and explains the value of the revised Law of the People’s Republic of China on Popularization of Science and Technology，its goal orientation，and puts forward a targeted implementation strategy，which is aimed at providing theoretical support and practical guidance for China’s science and technology popularization and assisting the high-quality development of the science and technology popularization. The purpose is to provide theoretical support and practical guidance for China’s science and technology popularization to serve the construction of Scientific and Technological Powerhouse，thereby contributing to the high-quality development of science and technology popularization.