Cutting-Edge science and technology resources are widely and abundantly present within innovation entities such as research universities，scientific research institutions，and high-tech enterprises. These resources possess characteristics of original innovation，leadership role，interdisciplinarity，disruptiveness，and high risk. Uncovering and disseminating their content in science popularization directly contributes to maximizing research benefits and enhancing public scientific literacy. Based on an analysis of the current state of the science popularization of cutting-edge science and technology resources domestically and internationally，this paper delves into the challenges faced by China in this regard，such as the lack of top-level design，ineffective conversion channels and the separation between creators and disseminators. Utilizing the 5W1H analytical method，a transformation model is constructed that encompasses four dimensions: drivers of transformation，agents of transformation，long-term and efficient transformation methods，and elements of transformation content. By analyzing the core principles，gradual logic，and practical case studies of the science popularization of cutting-edge science and technology resources，the paper proposes effective strategies from four perspectives：top-level design and guidance mechanisms，building a collaborative framework for socialized science popularization，applying combinatorial innovation methods，and providing multimodal popular science supply.