To solve the practical problem that the science popularization action of science and technology innovation main bodies is weak in the implementing and organizing system of science popularization in the whole society of China, the paper regarded science and technology innovation main bodies as the focus of high-level transformation of science popularization supply system in the new period. Based on the historical, theoretical and realistic logic analysis, the paper explained the basic meaning of strengthening science popularization supply of science and technology innovation subjects in the new period, and constructed a conceptual model of science popularization organization implementation with science and technology workers as the core, and analyzed its basic characteristics. At the same time, by fully drawing on the typical practices of relevant institutions of domestic and abroad, adhering to the general idea of continuing to strengthen policy guidance, we proposed to build a “three guarantees” comprehensive performance management system for knowledge producers, create an interest-driven mechanism for science popularization to help knowledge producers innovate and start businesses, and optimize online and offline science popularization communication networks according to the principle of party supervising propaganda, based on science popularization, we should explore academic exchanges and cooperation in the new era and other policy suggestions to guide the science popularization supply of science and technology innovation main bodies.