The paper visualizes and interprets the literature related to science popularization in CNKI from 2010 to 2019, which reveals the hotspots and the evolution trend of science popularization research. The research hotspots and their interrelationships are presented comprehensively and clearly in the usage of CiteSpace and Vosviewer. Specifically, in the past ten years, domestic science popularization research can be divided into two periods: steady development from 2010 to 2015 and comprehensive strategic upgrading from 2016 to 2019. The hotspots of domestic science popularization research have been evolving from the health, traditional media, weather, scientific literacy and natural disasters, to new topics such as artificial intelligence, integrated circuit, information platform construction, science popularization from the perspective of new media, etc., which will become new hotspots in the domestic science popularization studies in the future.