As the supply side of science popularization service, science museums meet the needs of visitors (as the demand side) so as to attract and keep the audience for completing the mission of upgrading public science understanding and elevating public science literacy by science popularization products as exhibitions, education activities and public services. It is an inevitable issue of science museums to supply high quality science popularization service. Based on IPA analysis, this paper constructs the index system of satisfaction and perceptive importance, and researches on staff members and visitors at Guangdong Science Center in the form of questionnaire survey. Meanwhile, this paper originally compared the IPA result between staffs and audience to propose the three steps of supply-side reform for science popularization service: enhancing the thoughts of audience-focused science popularization; meeting visitor needs by adjusting service supply, and guiding visitor needs when improving the service supply.