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Research progress and prospect of Ophiocordyceps gracilis in Xinjiang: resources, pharmacological activities, and artificial cultivation
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Xiaojing LIU1, Haodong GAN1, Tongyao LIU2, Wei DENG2, Xingzhong LIU2, Jing ZHU1, *, Zhidong ZHANG1, *
Mycosystema | 2026, 45(4) : 250319
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Mycosystema | 2026, 45(4): 250319
• Review •
Research progress and prospect of Ophiocordyceps gracilis in Xinjiang: resources, pharmacological activities, and artificial cultivation
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Xiaojing LIU1, Haodong GAN1, Tongyao LIU2, Wei DENG2, Xingzhong LIU2, Jing ZHU1, *, Zhidong ZHANG1, *
Affiliations
  • 1 Xinjiang Key Laboratory of Special Environmental Microbiology, National Microbial Germplasm Bank for Fertilizers (Xinjiang), Institute of Microbiology, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, Xinjiang, China
  • 2 State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China
Published: 2026-04-22 doi: 10.13346/j.mycosystema.250319
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A distinctive medicinal fungus-insect complex formed by Ophiocordyceps gracilis on the larvae of Ahamus altaicola in the Altai Mountains of Xinjiang, China, has demonstrated considerable potential in immunomodulation, antioxidant, antitumor, and antibacterial activities due to its richness of bioactive compounds, such as nucleosides, polysaccharides, cordycepic acid, and amino acids. This review systematically summarizes the research progress on O. gracilis, covering its taxonomy and nomenclature, resource distribution and biological characteristics, chemical composition, pharmacological activities, and artificial cultivation. Key current challenges are proposed including evaluation of natural distribution and resources, pharmaceutical activities, artificial cultivation, and in vivo efficacy and clinical trials. Future research directions are proposed, emphasizing the need to enhance natural resource ecology and conservation, elucidation of the mechanisms of fungus-host interaction, and establishment of a multi-dimensional quality control system. This review aims at providing a scientific framework to guide the sustainable utilization and advanced development of this valuable medicinal resource.

Ophiocordyceps gracilis  /  resource distribution  /  pharmacological activities  /  fungus-host interaction
Xiaojing LIU, Haodong GAN, Tongyao LIU, Wei DENG, Xingzhong LIU, Jing ZHU, Zhidong ZHANG. Research progress and prospect of Ophiocordyceps gracilis in Xinjiang: resources, pharmacological activities, and artificial cultivation[J]. Mycosystema, 2026 , 45 (4) : 250319 - . DOI: 10.13346/j.mycosystema.250319
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  • Project of Fund for Stable Support to Agricultural Sci-Tech Renovation(xjnkywdzc-2026002-7)
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Year 2026 volume 45 Issue 4
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Article Info
doi: 10.13346/j.mycosystema.250319
  • Receive Date：2025-11-13
  • Online Date：2026-04-30
  • Published：2026-04-22
Article Data
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History
  • Received：2025-11-13
  • Accepted：2025-12-02
Funding
Project of Fund for Stable Support to Agricultural Sci-Tech Renovation(xjnkywdzc-2026002-7)
Affiliations
    1 Xinjiang Key Laboratory of Special Environmental Microbiology, National Microbial Germplasm Bank for Fertilizers (Xinjiang), Institute of Microbiology, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, Xinjiang, China
    2 State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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