Non-alcoholic fatty liver disease (NAFLD) has gradually become an important factor causing hepatocellular carcinoma (HCC), and the clinical treatment effects of NAFLD-HCC and general liver cancer are significantly different, and there are many differences in drug sensitivity. At present, the pathogenesis of NAFLD-HCC is not yet clear. Therefore, it is particularly important to construct pre-clinical animal models of NAFLD-HCC. There are various induction methods for animal models of NAFLD-HCC, including dietary induction, chemical induction, genetic induction, dietary combined with chemical induction, genetic combined with dietary and other induction methods. More and more studies have found that there are certain differences in the histopathological types of animal models of NAFLD-HCC induced by different methods. Therefore, according to the research problem, choosing the most suitable animal model is of great significance for studying the causes of NAFLD-HCC and subsequent development of new drugs. The mouse models established for preclinical studies of the progression of NAFLD-HCC were summarized in this paper to reveal the pathogenesis of NAFLD-HCC, and to explore possible new targets for prevention or treatment of NAFLD-HCC.