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The role of vascular endothelial glycocalyx in the pathological mechanism, diagnosis and treatment of sepsis-related acute lung injury
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Jia-Di Chen1, Di Gong2, Yu-Hu Yi1, Yi Chen3, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(4) : 398 - 403
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(4): 398-403
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The role of vascular endothelial glycocalyx in the pathological mechanism, diagnosis and treatment of sepsis-related acute lung injury
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Jia-Di Chen1, Di Gong2, Yu-Hu Yi1, Yi Chen3, *
Affiliations
  • 1Emergency Department, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  • 2Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  • 3Department of Intensive Care Unit, Dongguan Hospital Affiliated to Jinan University, Dongguan, Guangdong 523900, China
Published: 2021-04-28 doi: 10.11855/j.issn.0577-7402.2021.04.13
Outline
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Vascular endothelial glycocalyx (VEG), a protein-polysaccharide complex located on the cell membrane of vascular endothelial cell lumen, has physiological effects such as anti-inflammation, anti-thrombosis and protection of endothelium.The structural and functional abnormalities of VEG in pulmonary capillaries play an important role in the occurrence and progression of sepsis-mediated acute lung injury (ALI). On one hand sepsis induces ALI by activating heparanase and destroying glycocalyx; on the other hand, it inhibits the repair of lung tissue by preventing the timely reconstruction of glycocalyx. This article summarizes the recent studies to explore the relationship between the structural and functional impairment of VEG and sepsis-related ALI, as well as the value and prospect of glycocalyx in the diagnosis and treatment of sepsis-related ALI.

vascular endothelial glycocalyx  /  sepsis  /  acute lung injury
Jia-Di Chen, Di Gong, Yu-Hu Yi, Yi Chen. The role of vascular endothelial glycocalyx in the pathological mechanism, diagnosis and treatment of sepsis-related acute lung injury[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (4) : 398 -403 . DOI: 10.11855/j.issn.0577-7402.2021.04.13
Funding
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  • Basic and Applied Basic Research Fund of Guangdong Province(2019A1515011777)
  • Scientific Research Project of Guangdong Bureau of Traditional Chinese Medicine(20201369)
Appendix
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Year 2021 volume 46 Issue 4
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.04.13
  • Receive Date：2020-08-12
  • Online Date：2025-12-26
  • Published：2021-04-28
Article Data
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History
  • Received：2020-08-12
  • Revised：2021-01-10
Funding
Basic and Applied Basic Research Fund of Guangdong Province(2019A1515011777)
Scientific Research Project of Guangdong Bureau of Traditional Chinese Medicine(20201369)
Affiliations
    1Emergency Department, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
    2Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
    3Department of Intensive Care Unit, Dongguan Hospital Affiliated to Jinan University, Dongguan, Guangdong 523900, China

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表12种不同金属材料的力学参数
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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