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Research progress of the curative effects of main active components of Astragalus membranaceus in treatment of diabetic nephropathy
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Hui-Ming Ni1, 2, Zhe-Yi Dong2, Xiang-Mei Chen1, 2, *
Medical Journal of Chinese People’s Liberation Army | 2021, 46(3) : 294 - 299
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Medical Journal of Chinese People’s Liberation Army | 2021, 46(3): 294-299
• Review •
Research progress of the curative effects of main active components of Astragalus membranaceus in treatment of diabetic nephropathy
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Hui-Ming Ni1, 2, Zhe-Yi Dong2, Xiang-Mei Chen1, 2, *
Affiliations
  • 1School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • 2Department of Nephrology, Chinese PLA General Hospital/Chinese PLA Institute of Nephrology/State Key Laboratory of Kidney Diseases/National Clinical Medicine Research Center for Chronic Kidney Diseases/ Beijing Key Laboratory of Kidney Diseases, Beijing 100853
Published: 2021-03-28 doi: 10.11855/j.issn.0577-7402.2021.03.13
Outline
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Diabetic nephropathy (DN) is a common complication of diabetes, and is one of the main causes of end stage renal disease (ESRD). At present, the practical therapeutic method for DN is still lacked due to unclear pathogenesis. However, as a traditional Chinese medicine, astragalus, especially Astragalus membranaceus, is commonly used in the treatment of DN. The main active ingredients of Astragalus membranaceus include astragaloside Ⅳ (AS-Ⅳ) and astragalus polysaccharide (APS), which can effectively reduce proteinuria and protect renal function. The mechanism of AS-Ⅳ and APS in treatment of DN was reviewed in present article including regulation of endoplasmic reticulum stress (ERS), anti-inflammatory, reducing cell apoptosis, inhibiting fibrosis, and regulating metabolism of sugar and lipid, in order to provide reference for the research and clinical application.

diabetic nephropathy  /  astragaloside Ⅳ  /  astragalus polysaccharide
Hui-Ming Ni, Zhe-Yi Dong, Xiang-Mei Chen. Research progress of the curative effects of main active components of Astragalus membranaceus in treatment of diabetic nephropathy[J]. Medical Journal of Chinese People’s Liberation Army, 2021 , 46 (3) : 294 -299 . DOI: 10.11855/j.issn.0577-7402.2021.03.13
Funding
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  • National Natural Science Foundation of China(81700629)
  • National Key Research and Development Program(2016YFC1305503)
  • National Key Research and Development Program(2018YFC1704203)
  • Science and Technology Project of Beijing(D171100002817002)
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Year 2021 volume 46 Issue 3
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Article Info
doi: 10.11855/j.issn.0577-7402.2021.03.13
  • Receive Date：2020-09-03
  • Online Date：2025-12-26
  • Published：2021-03-28
Article Data
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History
  • Received：2020-09-03
  • Revised：2020-12-26
Funding
National Natural Science Foundation of China(81700629)
National Key Research and Development Program(2016YFC1305503)
National Key Research and Development Program(2018YFC1704203)
Science and Technology Project of Beijing(D171100002817002)
Affiliations
    1School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
    2Department of Nephrology, Chinese PLA General Hospital/Chinese PLA Institute of Nephrology/State Key Laboratory of Kidney Diseases/National Clinical Medicine Research Center for Chronic Kidney Diseases/ Beijing Key Laboratory of Kidney Diseases, Beijing 100853

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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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